逍遥丸结合度洛西汀在老年女性抑郁症患者中的治疗价值

Therapeutic Value of Xiaoyao Pill Combined with Duloxetine in Elderly Female Patients with Depression

目的探讨逍遥丸结合度洛西汀在老年女性抑郁症患者中的治疗价值。方法择取2020年1月—2021年6月兰陵县精神卫生中心收治的老年女性抑郁症患者48例,依据抛硬币法纳入Ⅰ组、Ⅱ组,每组24例。Ⅰ组应用度洛西汀治疗,Ⅱ组应用逍遥丸结合度洛西汀治疗,对比两组临床效果。结果Ⅱ组总有效率91.67%高于Ⅰ组66.67%,差异有统计学意义(χ^(2)=4.547,P=0.032);Ⅱ组睡眠质量和SCL-90因子评分优于Ⅰ组,差异有统计学意义(P<0.05);Ⅱ组不良反应发生率8.33%低于Ⅰ组37.50%,差异有统计学意义(χ^(2)=5.778,P=0.016)。结论针对老年女性抑郁症患者,运用逍遥丸、度洛西汀联合治疗方案可显著增强临床疗效,降低药物不良反应,值得推广。

Objective To investigate the therapeutic value of Xiaoyao pill combined with duloxetine in elderly female patients with depression.Methods 48 elderly female patients with depression admitted to Lanling County Mental Health Center from January 2020 to June 2021 were selected and included in group I and group II according to the coin tossing method,with 24 cases in each group.Group I was treated with du⁃loxetine,and group II was treated with Xiaoyao pill Combined with duloxetine.The clinical effects of the two groups were compared.Results The total effective rate in group II was 91.67%higher than that in group I 66.67%,and the difference was statistically significant(χ^(2)=4.547,P=0.032);the sleep quality and SCL-90 factor score in group II were better than those in group I,and the difference was statistically significant(P<0.05);the incidence of adverse reactions in group II was 8.33%,lower than 37.50%in group I,and the difference was statistically signifi⁃cant(χ^(2)=5.778,P=0.016).Conclusion For elderly female patients with depression,the application of Xiaoyao pill and duloxetine combined therapy can significantly enhance clinical efficacy and reduce drug side effects,which is worthy of promotion.