人乳头瘤病毒亚型分布与宫颈病变的关系

Correlations between human papillomavirus subtype distribution and cervical lesions in Nanchang

目的分析南昌地区人乳头瘤病毒(HPV)亚型分布特点,探究HPV分型与宫颈癌前病变的关系。方法选取在江西省南昌市第一医院检查的5803例女性患者作为临床研究对象,分析南昌地区HPV亚型分布、不同年龄组HPV感染情况,并分析其与宫颈癌前病变的相关性。结果分析发现患者中高危HPV感染率为75.42%,感染率居前的亚型分别为HPV 52、58、16亚型,占比分别为25.17%、14.10%、13.81%。>60岁年龄组的高危HPV感染率最高,在宫颈病变组织中以单一高危HPV亚型感染为主,感染率居前的分别是HPV 16(31.05%)、HPV 52(26.32%)、HPV 58(13.68%)、HPV 18(10.00%)亚型。结论南昌地区HPV流行的主要型别为52、58、16亚型,需要重视60岁以上及高危HPV 16、52、58、18亚型患者的阴道镜分流管理,以防止宫颈癌漏检。

Objective To analyze the characteristics of human papillomavirus(HPV)subtypes in Nanchang and explore the relationship between HPV typing and cervical precancerous lesions.Methods Female patients(n=5803)examined in the gynecological clinic of the First Hospital of Nanchang were selected.The distribution of HPV subtypes and HPV infection in different age groups were analyzed by Chi-square test,and their correlations with cervical precancerous lesions were analyzed.Results The analysis showed that the infection rate of high-risk HPV in patients was 75.42%,and the highest infection rates were found in HPV 52,58 and 16 subtypes,with positive rates of 25.17%,14.10%and 13.81%,respectively.The high-risk HPV infection rate was the highest in the 60 year old age group.The single high-risk HPV subtype was the main infection in cervical lesions.The highest infection rates were HPV 16(31.05%),HPV 52(26.32%),HPV 58(13.68%)and HPV 18(10.00%).Conclusion The main subtypes of HPV prevalence in Nanchang are subtypes 52,58 and 16.It is necessary to pay attention to colposcopy shunt management in patients over 60 years old with high-risk HPV 16,52,58 and 18 subtype infection.