PLA2R抗原表位及其抗体在特发性膜性肾病中的研究进展

Research Progresses of PLA2R Epitope and Its Antibody in Idiopathic Membranous Nephropathy

特发性膜性肾病(idiopathic membranous nephropathy,IMN)是一种自身免疫性疾病,是临床上导致成人肾病综合征的主要原因之一。它产生的主要原因是体内含量极低的蛋白类物质,如M型磷脂酶A2受体(M-type phospholipase A2 receptor,PLA2R)含量的升高,对肾脏的膜的滤过作用产生影响,引起机体的一系列免疫反应。该文主要介绍了近年来人们对IMN血清标志物、PLA2R抗原及抗体的研究,尤其是对PLA2R抗原表位的研究,整合了PLA2R抗原表位变化与IMN的分层预后的相关信息。希望可以通过对已知信息的整合,探求IMN诊断治疗未来的研究方向。

IMN (idiopathic membranous nephropathy) is an autoimmune disease and one of the main clinical causes of nephrotic syndrome in adults.The main reason for its occurrence is the increase of the protein with very low content in the body,such as PLA2R (M-type phospholipase A2 receptor),have an impact on the filtration of the kidney’s membrane,causing a series of immune responses of the body.This article mainly introduces the research on IMN serum markers,PLA2R antigen and antibody in recent years,especially the research on the PLA2R epitope,and integrates the correlation information between the changes of PLA2R epitope and the stratified prognosis of IMN.It is hoped that through the integration of known information,future research directions for the diagnosis and treatment of IMN can be explored.