摘要
目的探讨补肾泄浊方联合厄贝沙坦片治疗早期糖尿病肾病的临床效果及对氧化应激的影响。方法选择2019年1月—2020年6月九江市中医院早期糖尿病肾病住院患者96例,将其分为对照组和治疗组,各48例,对照组予厄贝沙坦片治疗,治疗组联合补肾泄浊方治疗,检测2组尿白蛋白排泄率(UAER)、糖化血红蛋白(HbA1c)、血清同型半胱氨酸(Hcy)、胱抑素C(Cys C)、超氧化物歧化酶(SOD)及丙二醛(MDA)的变化,观察2组的临床疗效。结果治疗组治疗总有效率为89.6%(43/48)高于对照组的68.8%(33/48)(P<0.05);治疗后,治疗组UAER、HbA1c、Hcy、CysC、MDA及SOD水平均低于对照组,差异均有统计学意义(P<0.05或P<0.01);2组患者均无明显不良反应。结论补肾泄浊方联合厄贝沙坦片治疗早期糖尿病肾病可以有效提高临床效果,降低UAER、HbA1c、Hcy及Cys C水平,调节氧化应激状态,值得推广。
Objective To investigate the clinical effect of Bushen Xiezhuo prescription combined with irbesartan tablets in the treatment of early diabetic nephropathy and its influence on oxidative stress.Methods A total of 96 inpatients with early diabetic nephropathy in Jiujiang Hospital of Traditional Chinese Medicine from January 2019 to June 2020 were selected and divided into control group and treatment group,48 cases in each group.The control group was treated with irbesartan tablets,and the treatment group was treated with Bushen Xiezhuo prescription.The changes of urinary albumin excretion rate(UAER),glycosylated hemoglobin(HbA1c),serum homocysteine(Hcy),cystatin C(Cys C),superoxide dismutase(SOD)and malondialdehyde(MDA)in the two groups were detected,and the clinical efficacy of the two groups was observed.Results The total effective rate of the treatment group was 89.6%(43/48),which was higher than 68.8%(33/48)of the control group(P<0.05).After treatment,the levels of UAER,HbA1c,Hcy,CysC,MDA and SOD in the treatment group were lower than those in the control group,and the differences were statistically significant(P<0.05 or P<0.01).Conclusion Bushen Xiezhuo prescription combined with irbesartan tablets can effectively improve the clinical effect of early diabetic nephropathy,reduce UAER,HbA1c,Hcy and Cys C levels,regulate oxidative stress.It’s worth promoting.
作者
李金花
宗海涛
李亚宁
魏林
LI Jinhua;ZONG Haitao;LI Yaning;WEI Lin(Department of Nephrology,Jiujiang Hospital of Traditional Chinese Medicine,Jiangxi Province,Jiujiang 332000,China)
出处
《中国中医药现代远程教育》
2022年第18期117-120,共4页
Chinese Medicine Modern Distance Education of China
基金
江西省中医药管理局一般基金项目【No.2019A445】。
关键词
消渴
水肿
补肾泄浊方
厄贝沙坦片
糖尿病肾病
氧化应激
中西医结合疗法
consumptive thirst
edema
Bushen Xiezhuo prescription
irbesartan tablets
diabetic nephropathy
oxidative stress
therapy of integrated traditional Chinese and western medicine