活性氧在敌草快中毒中的作用机制研究进展

The mechanism of reactive oxygen species and pharmacological therapy in diquat poisoning

敌草快(DQ)是一种非选择性速效除草剂,具有较强的毒性作用,人体和动物摄入后可以导致中毒的发生。DQ的毒性源于其通过氧化还原循环过程产生活性氧(ROS),并进一步引起氧化应激,最终导致细胞和组织损伤。临床上尚无DQ中毒的治疗指南,目前无特效解毒药物。本文主要介绍DQ中毒后,ROS使机体细胞损伤的作用机制及药理学靶点研究进展,为以后DQ中毒的研究提供基础。

Diquat(DQ), a-non selective quick-acting herbicide, is highly toxic to humans and livestock after ingestion. The toxicity of DQ comes from the production of reactive oxygen species(ROS) through redox cycle, which further causes oxidative stress, eventually leading to cell and tissue damage. There is no clinical treatment guideline for DQ poisoning. This review mainly introduces the research advances on the mechanism of ROS and pharmacological targets in diquat poisoning, so as to provide foundation for the research of DQ poisoning in the future.