摘要
中长链游离脂肪酸不仅是机体重要的能量来源,也是机体免疫中重要的信号分子。近年来研究表明,中长链游离脂肪酸通过与游离脂肪酸受体(free fatty acid receptors,FFAR)1和FFAR4互作,调节胰岛素分泌和炎症反应来进一步调节机体免疫代谢。本综述讨论了有关中长链游离脂肪酸饮食以及在体内的代谢,重点介绍了中长链游离脂肪酸及其受体介导的信号途径对味觉信号传导、代谢调节和免疫应答中的关键生理功能影响及合成激动剂的研究进展。
Medium-and long-chain free fatty acids are not only an important source of energy for the body, but also important signal molecules in the body’s immunity. Recent studies have shown that medium-and long-chain free fatty acids interact with free fatty acid receptors(FFARs) 1 and 4 to regulate insulin secretion and inflammation and in turn the body’s immune system and metabolism. In this review, we discuss the nutritional role and metabolism of dietary medium-and longchain free fatty acids in the body, focusing on the latest progress in understanding the key physiological functions of medium and long-chain free fatty acids and their receptor-mediated signal pathways in taste signal transduction, metabolic regulation,and immune response and in research on synthetic agonists of FFAR1 and FFAR4.
作者
郑子晴
牛博
鲁丁强
庞广昌
ZHENG Ziqing;NIU Bo;LU Dingqiang;PANG Guangchang(School of Biotechnology and Food Science,Tianjin University of Commerce,Tianjin 300134,China;Tianjin Key Laboratory of Food Biotechnology,Tianjin 300134,China)
出处
《食品科学》
EI
CAS
CSCD
北大核心
2022年第19期249-261,共13页
Food Science
基金
国家自然科学基金面上项目(31671857)
国家自然科学基金青年科学基金项目(31901782)。
