摘要
急性心肌梗死(acute myocardial infarction,AMI)是心血管疾病中最严重类型,可导致心律失常、心力衰竭甚至猝死,近年来研究表明炎症反应与AMI的发生、发展及心肌梗死后的损伤修复密切相关。各种炎症细胞作为人体免疫系统的重要部分,参与了AMI的发生及发展。中性粒细胞/淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)、淋巴细胞/单核细胞比值(lymphocyte/monocyte ratio,LMR)及全身免疫炎症指数(systemic immune inflammation index,SII)等炎症相关衍生指标可反映机体炎症状态,已被大量研究发现其在AMI诊断、治疗、预后及并发症方面存在一定预测价值。该文主要对炎症相关衍生指标在与AMI中的作用进行综述,以期为AMI发病机制及治疗提供新的依据。
Acute myocardial infarction(AMI)is the most serious type of cardiovascular disease,which can lead to arrhythmia,heart failure and even sudden death.Recent studies have shown that inflammatory response is closely related to the occurrence and development of AMI and the damage repair after myocardial infarction.As an important part of human immune system,various inflammatory cells are involved in the occurrence and development of AMI.Inflammation-related derived indicators such as NLR,LMR and SII can reflect the inflammatory state of the body,and a large number of studies have found that they have certain predictive value in the diagnosis,treatment,prognosis and complications of AMI.This article mainly reviews the role of inflammation-related derived indicators in AMI,in order to provide a new basis for the pathogenesis and treatment of AMI.
作者
王家琦
吴路路
张飞飞
高曼
党懿
齐晓勇
WANG Jia-qi;WU Lu-lu;ZHANG Fei-fei;GAO Man;DANG Yi;QI Xiao-yong(Graduate School of Hebei North University,Zhangjiakou,075000,China;Department of Cardiology,Hebei General Hospital,Shijiazhuang,050051,China)
出处
《神经药理学报》
2022年第3期11-16,共6页
Acta Neuropharmacologica
基金
河北省自然科学基金项目(No.H2020307017)
河北省2019年度医学科学研究课题项目(No.20190237)。
