胰岛素不同使用方式在儿童糖尿病中的治疗效果

The Therapeutic Effect of Different Insulin Use Methods in Childhood Diabetes Mellitus

目的 探讨胰岛素不同使用方式在儿童糖尿病中的治疗效果。方法 回顾性分析福建省平潭综合实验区医院门诊于2020年6月—2021年12月接诊随访的38例糖尿病患儿,所有患儿均接受胰岛素治疗,以胰岛素使用方式的不同作为分组依据,将皮下注射胰岛素的患儿纳入皮下注射组(n=18),进行胰岛素泵治疗的患儿则纳入胰岛素泵组(n=20)。治疗3个月后,比较两组糖化血红蛋白(HbA1c)、餐后2 h血糖(2 hPG)、空腹血糖(FPG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)以及三酰甘油(TG),观察两组低血糖发生率。结果 治疗后,胰岛素泵组HbA1c、2 hPG、FPG、LDL-C、HDL-C、TG水平均优于皮下注射组,差异有统计学意义(P<0.05);胰岛素泵组低血糖发生率为0.00%,较皮下注射组的27.78%低,差异有统计学意义(P<0.05)。结论 对糖尿病患儿采用胰岛素泵治疗效果较皮下注射更优,能在改善患儿血糖水平的同时发挥有效调脂作用并能减少低血糖发生风险。

Objective To investigate the therapeutic effect of different insulin use methods in children with diabetes.Methods A retrospective analysis was performed of 38 children with diabetes who were admitted to the outpatient clinic of Pingtan Comprehensive Experimental Area Hospital in Fujian Province from June 2020 to December 2021.All children received insulin therapy,and the differences in insulin use were used as the basis for grouping.Children who received subcutaneous insulin injection were included in the subcutaneous injection group(n=18),and those who received insulin pump therapy were included in the insulin pump group(n=20).After 3 months of treatment,The glycosylated hemoglobin(HbA1c),2 h postprandial blood glucose(2 hPG),fasting blood glucose(FPG),low density lipoprotein cholesterol(LDL-C),high density Lipoprotein cholesterol(HDL-C) and triglyceride(TG) were compared between the two groups and observe the incidence of hypoglycemia in the two groups.Results After treatment,the levels of HbA1c,2 hPG,FPG,LDL-C,HDL-C and TG in the insulin pump group were better than those in the subcutaneous injection group,and the difference was statistically significant(P<0.05).The incidence of hypoglycemia in the insulin pump group was 0.00% lower than that in the subcutaneous injection group 27.78%,and the difference was statistically significant(P<0.05).Conclusion The therapeutic effect of insulin pump in children with diabetes is better than subcutaneous injection.It can improve the blood glucose level of children while exerting an effective lipidregulating effect and reduce the risk of hypoglycemia.