乙酰半胱氨酸联合布地奈德雾化吸入治疗支气管肺炎患儿的效果

Effect of Acetylcysteine Combined with Budesonide Inhalation in the Treatment of Children with Bronchial Pneumonia

目的探讨支气管肺炎患儿采用乙酰半胱氨酸联合布地奈德雾化吸入治疗的临床疗效。方法选择2021年2月—2022年2月徐州市妇幼保健院收治的支气管肺炎患儿118例作为研究对象,随机数表法分为两组,各59例。两组均给予对症支持治疗,对照组采用乙酰半胱氨酸雾化吸入治疗,观察组采用乙酰半胱氨酸联合布地奈德雾化吸入治疗,治疗7 d后评估患儿效果,比较两组治疗有效率、症状缓解情况、炎性介质水平及药物不良反应情况。结果观察组患儿治疗7 d后有效率为94.92%,高于对照组的81.36%,差异有统计学意义(χ^(2)=5.187,P<0.05);观察组患儿治疗期间体温恢复正常时间(2.49±0.57)d、肺部啰音消失时间(4.67±0.78)d、咳嗽消失时间(5.42±0.51)d均短于对照组患儿,差异有统计学意义(t=8.605、6.561、6.556,P<0.05);治疗7 d后观察组患儿CRP水平(2.15±0.79)mg/L、PCT水平(0.03±0.01)ng/mL均低于对照组患儿,差异有统计学意义(t=13.338、5.431,P<0.05);两组患儿用药期间出现鼻干口干、皮疹、恶心呕吐及腹泻的总发生率(6.78%vs 3.39%)对比,差异无统计学意义(P>0.05)。结论支气管肺炎患儿采用乙酰半胱氨酸联合布地奈德雾化吸入治疗,可提高治疗有效率,促进患儿症状快速缓解,降低炎性介质水平,且未增加药物不良反应,值得推广应用。

Objective To investigate the clinical efficacy of acetylcysteine combined with budesonide inhalation in the treatment of children with bronchopneumonia.Methods A total of 118 children with bronchial pneumonia admitted to Xuzhou Maternal and Child Health Hospital from February 2021 to February 2022 were selected as the study subjects and divided into two groups by random number table method,with 59 cases in each.Both groups were given symptomatic and supportive treatment,the control group was given acetylcysteine atomization inhalation therapy,and the observation group was given acetylcysteine combined with budesonide atomization inhalation therapy.After 7 days of treatment,the efficacy of the children was evaluated,and the treatment efficacy,symptom relief,inflammatory mediator levels and adverse drug reactions were compared between the two groups.Results After 7 days of treatment,the effective rate in the observation group was 94.92%higher than that in the control group,which was 81.36%,and the difference was statistically significant(χ^(2)=5.187,P<0.05).During the treatment period,the time for body temperature to return to normal(2.49±0.57)d,the time for pulmonary rales to disappear(4.67±0.78)d,and the time for cough to disappear(5.42±0.51)d were all shorter than those in the control group,the difference was statistically significant(t=8.605,6.561,6.556,P<0.05).After 7 days of treatment,the CRP level(2.15±0.79)mg/L and the PCT level(0.03±0.01)ng/mL of the observation group were lower than those of the control group,and the difference was statistically significant(t=13.338,5.431,P<0.05).There was no statistically significant difference in the total incidence of dry nose,dry mouth,skin rash,nausea,vomiting and diarrhea between the two groups(6.78%vs 3.39%)(χ^(2)=0.176,P>0.05).Con⁃clusion In children with bronchopneumonia,acetylcysteine combined with budesonide aerosol inhalation therapy can improve the effective rate,promote the rapid relief of symptoms in children,reduce the level of inflammatory mediators,and does not increase the adverse drug reactions,which is worthy of popularization and application.