糖尿病性白内障患者血糖指标水平

Blood glucose levels in patients with diabetes cataract

目的:观察糖尿病性白内障患者的空腹血糖(FPG)、糖化血红蛋白(HbA1c)、胰岛素抵抗指数(HOMA-IR)水平,并分析其临床意义。方法:选取糖尿病性白内障患者为观察对象,选取同期接受治疗的单纯白内障患者为对照组。观察两组患者FPG、HbA1c、HOMA-IR、炎性因子和视力相关指标的差异,分析糖尿病性白内障患者FPG、HbA1c、HOMA-IR水平与炎性因子和视力相关指标的相关性。结果:观察组FPG、HbA1c、HOMA-IR水平高于对照组,差异有统计学意义(t=-16.826、-14.552、-16.474,P<0.001);观察组的视力低于对照组,眼压高于对照组,差异有统计学意义(P<0.001);观察组的血清白细胞介素-6(IL-6)、血清胰岛素样生长因子(IGF-1)、血管内皮生长因子(VEGF)水平高于对照组,差异有统计学意义(t=-66.579、-47.309、-66.349,P<0.001);糖尿病性白内障患者的FPG、HbA1c、HOMA-IR水平与视力呈负相关,与眼压、IL-6、IGF-1、VEGF水平呈正相关,差异有统计学意义(P<0.05)。结论:糖尿病性白内障患者的FPG、HbA1c、HOMA-IR水平较高,且与患者的视力、眼压和炎性因子水平密切相关。

Objective To observe the levels of FPG,HbA1c and HOMA-IR in patients with diabetic cataract and analyze their clinical significance.Method The patients with diabetic cataract were selected as the observation objects,and the patients with simple cataract treated in our hospital during the same period were selected as the control group.The differences of FPG,HbA1c,HOMA-IR,inflammatory factors and visual acuity related indicators between the two groups were observed.The correlation between FPG,HbA1c,HOMA-IR and inflammatory factors and visual acuity related indicators in diabetic cataract patients was analyzed.Results The levels of FPG,HbA1cand HOMA-IR in the observation group were higher than those in the control group(t=-16.826,-14.552,-16.474,P<0.001).The visual acuity of the observation group was lower than that of the control group,and the intraocular pressure of the observation group was higher than that of the control group(P<0.001).The levels of IL-6,IGF-1 and VEGF in the observation group were higher than those in the control group(t=-66.579,-47.309,-66.349,P<0.001).The levels of FPG,HbA1c and HOMA-IR in diabetic cataract patients were negatively correlated with visual acuity,and positively correlated with intraocular pressure,IL-6,IGF-1 and vascular endothelial growth factor(P<0.05).Conclusion The levels of FPG,HbA1c and HOMA-IR in diabetic cataract patients are higher,and they are closely related to the visual acuity,intraocular pressure and inflammatory factors.