摘要
CKLF样MARVEL跨膜结构域成员(CMTM)家族是一种新基因家族,CMTM6是其中重要一员。程序性死亡配体1(PD-L1)是一种免疫检查点抑制分子,其可参与介导肿瘤细胞的免疫逃逸。研究表明,CMTM6与PD-L1结合后,可稳定细胞表面PD-L1的表达,从而实现肿瘤细胞的免疫逃逸,提示CMTM6可能在调节肿瘤细胞免疫抑制方面起着一定的作用,继而为肿瘤的免疫治疗提供了新的思路。本篇综述对CMTM6及其在消化系统肿瘤中的研究进展进行作一介绍。
CKLF-like MARVEL trans-membrane domain-containing member(CMTM)is a new gene family,and CMTM6 is an important member.Programmed death ligand 1(PD-L1)is an inhibitory immune checkpoint molecules and participates in mediating the immune escape of tumor cells.Studies have shown that the combination of CMTM6 and PD-L1 can stabilize the expression of PD-L1 on the cell surface and realize the immune escape of tumor cells,suggesting that CMTM6 may play a certain role in regulating tumor immune suppression,thereby providing a new idea for the immunotherapy of tumors.This review briefly introduces the progress in research of CMTM6 in digestive system tumors.
作者
侯志远
孟明
邹静雯
滕景芳
陈乾
程树杰
HOU Zhi-yuan;MENG Ming;ZOU Jing-wen;TENG Jing-fang;CHEN Qian;CHENG Shu-jie(Department of Hepatobiliary Surgery,the Affiliated Hospital of Hebei University,Baoding,Hebei 071000,China;不详)
出处
《中国临床研究》
CAS
2022年第11期1582-1586,共5页
Chinese Journal of Clinical Research
基金
河北省自然科学基金(18277790D)。
关键词
CMTM6
程序性死亡配体1
人类趋化素样因子超家族
消化道肿瘤
免疫逃逸
免疫抑制
CKLF-like MARVEL transmembrane domain-containing member 6
Programmed death ligand 1
Human chemokine-like factor superfamily
Gastrointestinal tumors
Immune escape
Immune suppression
