新型多功能血浆单采机管路的设计与应用

Design and application of a new type of mulitifunctional plasma collector pipeline

目的:研制一套新型血浆单采设备上使用的管路,将血浆单采和病毒灭活融为一体,适用于临床病毒感染性疾病的血液治疗。方法:在现有血浆采集管路的基础上,将采血、离心分离、血浆收集、光敏剂添加和吸附去除整体全封闭于一体的采血管路,血浆收集袋后方串联一套血浆病毒灭活袋,二者之间并联光敏剂添加件和吸附过滤器,在管路适当的位置上分别设置止流夹,于采血管路回输端并联一套输血器,用于将灭活后的血浆回输给患者。结果:经过改良后的新型单采血浆病毒灭活管路在血浆单采机上安装运行良好,实现了由原来的单一采浆功能升级至血浆+病毒灭活治疗于一体的多功能管路,为临床病毒感染患者血液治疗提供了极大的便利。结论:成功设计了一套适用于机采设备使用的全封闭新型血浆病毒灭活管路,在血液采集、血浆处理和回输方面更加安全和程序化。用于病毒感染疾性病患者血液残余病毒灭活治疗,简化操作流程,降低操作者病毒感染风险,提高救治时效性,新型管路亦可用于单采血浆站采血和病毒灭活,对提高血浆生物制品安全性意义重大,值得临床和单采血浆站推广应用。

Objective: To design a set of plasma virus inactivation lines suitable for plasma collection equipment, complexing blood collection and treatment in one, which was used to blood therapy for viral infectious diseases. Methods: Based on the existing plasma collection line, a series of procedures such as blood collection, centrifuge, plasma collection, photo sensitizer addition and adsorption removal were entire full-enclosed one blood collection pipeline. Three plasma virus inactivation bags were set in series behind the plasma collection bag. The devices of photo sensitizer and filter were set in parallel between plasma collection bag and the inactivation bag. The clips were provided in the appropriate position of the pipe line. A blood transfusion was connected in parallel at the front end of the blood collection line for inactivating postal plasma return to the patient. Results: After the simulation test, the improved plasma virus inactivation pipeline was well installed on plasma collecting equipment. It was achieved a multifunctional pipeline and upgraded from the original single gel function to plasma + virus inactivation. It provided great convenience for blood purification treatment for the clinical virus infection. Conclusion: We successfully designed a full enclosed new plasma virus inactivation pipeline for the equipment. The treatment was safer and more programmed in blood collection, plasma treatment and return. The operational process of blood residual virus inactivated was more simplified, so reduced the risk of operator viral infection and improved the treatment timelines. The new pipeline could also be used for the plasma station and viral inactivation. It was very important for improving the biological safety of plasma products. It was worth clinical application and plasma collection stations.