国内外患者报告结局的应用现状与研究进展

Patient-reported Outcome:Recent Advances in Applications and Research at Home and Abroad

患者报告结局(PRO)为直接来自患者报告的自身健康状况、功能状态及治疗感受等方面的信息,不包括医护人员及其他人员的解释。倾听来自患者的声音,有利于提高医疗服务质量与治疗满意度。本研究梳理了PRO在国内外药品审评审批与药械监管、医疗服务质量评价、卫生技术评估、药品临床综合评价等领域的应用现状,并且综述了近年来PRO量表研制、健康效用积分体系构建、儿童青少年健康测量、PRO测量工具的质量评价等国内外研究进展。最后建议未来应加强本土化PRO工具的研制与开发,重视PRO与临床实践相结合,同时应加强PRO研究学科间交叉及研究内容的深化,从而更好地促进我国PRO研究与应用的发展。

Patient-reported outcome(PRO)refers to any information about the patient's own health condition,functional status,and feelings about treatment that directly comes from the patient without interpretation by physicians,nurses or anyone else.Measuring outcomes from the patient perspective is conducive to improving the quality of medical services and treatment satisfaction.We summarized recent applications of PRO in many fields,such as drug review and approval,drug and medical equipment supervision,quality evaluation of medical services,health technology assessment,and comprehensive clinical evaluation of drugs,and reviewed the latest advances in research on PRO,such as the development of PRO instruments,the construction of a health state utility value set,the health measurement in children and adolescents,and the quality evaluation of PRO instruments.Then we put forward recommendations to further promote the studies and use of PRO in China:strengthening the development of PRO instruments applicable to China,valuing the use of PRO in clinical practice,enhancing the interdisciplinary research on PRO,broadening the profile of research on PRO,and intensifying relevant research.