影响胰腺癌切除术后患者预后的相关危险因素分析

Analysis of Relevant Risk Factors Affecting Patient Outcomes After Resection of Pancreatic Cancer

目的 探讨影响胰腺癌切除术后患者预后的相关危险因素。方法 回顾性分析行手术治疗的182例胰腺癌患者临床资料。分析影响胰腺癌切除术后患者预后的相关危险因素。结果 182例胰腺癌切除术后2年存活33例(18.13%)。单因素分析显示:临床分期、肿瘤大小、淋巴结转移、CD44v6、ⅡA分泌型磷脂酶A2(sPLA2-ⅡA)、整合素β1、手术切缘、神经侵犯与胰腺癌切除术后患者预后有关(P<0.05),年龄、性别、分化程度、肿瘤位置、血管侵犯、手术方式、术后化疗与胰腺癌切除术后患者预后无关(P>0.05);多因素分析显示:临床分期Ⅲ~Ⅳ期、肿瘤大小≥4 cm、淋巴结转移、CD44v6≥2.87 ng/μL、sPLA2-ⅡA≥0.68 ng/mL、整合素β1≥1.68 ng/μL、手术切缘阳性、神经侵犯是影响胰腺癌切除术后患者预后的高危因素(P<0.05)。结论 胰腺癌切除术后患者预后受临床分期、肿瘤大小、淋巴结转移、CD44v6、sPLA2-ⅡA、整合素β1、手术切缘、神经侵犯等因素影响。

Objective To investigate the relevant risk factors affecting the outcome of patients after resection of pancreatic cancer.Methods The clinical data of 182 patients with pancreatic cancer were retrospectively analyzed.To analyze the relevant risk factors affecting patient outcomes after pancreatic cancer resection.Results 182 pancreatic cancers resection 2 years 33(18.13%).Univariate analysis showed that: clinical stage, tumor size, lymph node metastasis, CD44v6,A secreted phospholipase A2(sPLA 2-A),integrin β 1,surgical margin, nerve invasion were related to the prognosis of patients after pancreatic cancer resection(P<0.05),Age, sex, differentiation degree, tumor location, vascular invasion, surgical method, and postoperative chemotherapy were not related to the prognosis of patients after pancreatic cancer resection(P>0.05);Multivariate analysis showed that: clinical stage ~ stage, tumor size 4 cm, lymph node metastasis, CD44v6 2.87 ng/μ L,sPLA 2-A 0.68 ng/mL,integrin β 11.68 ng/μ L,positive surgical margin, and nerve invasion were the high risk factors affecting the prognosis of patients after pancreatic cancer resection(P<0.05).Conclusion The prognosis of patients after pancreatic cancer resection is influenced by clinical stage, tumor size, lymph node metastasis, CD44v6,sPLA 2-A,integrin β 1,surgical margins, and nerve invasion.