湖北十堰地区女性HPV感染分布及类型特征分析

Distribution and type characteristics of HPV infection of women in Shiyan,Hubei Region

目的分析湖北十堰地区女性不同人乳头瘤病毒(HPV)亚型感染分布特点及类型特征,旨在为HPV感染的防治提供依据。方法随机抽取2019年1月至2020年12月湖北十堰地区有性生活的3180例女性作为研究对象,采用导流杂交法对其进行HPV基因亚型检测,观察不同年龄段女性HPV感染年龄段分布特点和HPV基因类型。结果3180例受检人群中,以31~50岁年龄段的妇女最多,其中31~40岁占比25.85%(822/3180)、41~50岁占比22.08%(702/3180);≤25岁和>60岁年龄段的人群最少,分别为428例、289例。3180例女性中1310例发生HPV感染,阳性率为41.19%(1310/3180)。HPV感染率以≤25岁、≥60岁年龄段人群最高,分别占比56.78%、67.13%。各年龄段中主要感染类型为单重感染,占比76.03%。受检者中检出21种HPV基因亚型,共有1918株病毒,单重感染主要高危亚型为HPV16、52、58,分别占比13.92%、13.87%、12.57%,其次为53、33,所占比分别为7.61%、5.58%;低危亚型主要为HPV11、8、6,所占比分别为7.51%、5.47%、5.01%。结论湖北十堰地区女性HPV感染率主要以≤25岁、≥60岁年龄段人群最高,临床应尽早对该地区人群进行筛查,针对高危型HPV分型实施疫苗注射等预防性方案。

Objective To analyze the distribution and type characteristics of human papillomavirus(HPV)infection in women in Shiyan,Hubei region,so as to provide a basis for the prevention and treatment of HPV infection.Methods From January 2019 to December 2020,a sample of 3,180 women in XX region who had sexual intercourse experience were randomly selected,and their HPV genotypes were tested using flow-through hybridization,then the distribution characteristics and types of HPV infection in women of different ages were observed.Results Among of 3180 patients,HPV infection was predominant in women aged 31-50 years,with 25.85%(822/3180)aged 31-40 years and 22.08%(702/3,180)aged 41-50 years.HPV infection was the least prevalent in the≤25 and>60 years age groups,with 428 cases and 289 cases respectively.HPV infection occurred in 1310 out of 3180 women,with a positive infection rate of 41.19%(1310/3180).HPV infection was most prevalent in the≤25 years and≥60 years age groups,accounting for 56.78%and 67.13%respectively.Single infection was the main infection type in all age groups,accounting for 76.03%.Twenty-one HPV genetic subtypes were detected in the subjects,out of a total of 1918 strains of the virus.The main high-risk subtypes for single infection were HPV16,HPV52 and HPV58,accounting for 13.92%,13.87%and 12.57%respectively,followed by HPV53 and HPV33,accounting for 7.61%and 5.58%respectively.The predominant low-risk subtypes for single infection were HPV11,HPV8 and HPV6,with accounting for 7.51%,5.47%and 5.01%respectively.Conclusion HPV infection in women in Shiyan,Hubei region is predominantly in the≤25 and≥60 years age groups,and early clinical screening and preventive measures such as vaccination for high-risk HPV typing are of vital importance.