摘要
通过梳理中医古籍文献并结合现代相关研究,探讨中医脾肾同治在肌少症治疗中的应用,认为肌少症的病位在筋脉肌肉,主要病变脏腑在脾,与肾密切相关,病机为脾肾虚衰、筋肉失养,治疗应以健脾补肾为主,其作用机制可能与改善线粒体功能、降低炎性细胞因子水平、促进胰岛素分泌、修复肌纤维等有关。
The aim of the study is to explore the application of simultaneous treatment of spleen and kidney in the treatment of sarcopenia by sorting TCM literature and related research.It is believed that the location of sarcopenia is in the muscles and sinews,and the main pathological changes are located in the spleen and kidney,which is closely related to the kidney.The pathogenesis is deficiency of the spleen and kidney,muscle deprived of nourishment,and the treatment should focus on invigorating spleen and tonifying kidney.The mechanism of invigorating spleen and tonifying kidney in the treatment of sarcopenia may be related to improving mitochondrial function,reducing inflammatory factors,promoting insulin secretion and repairing muscle fibers.
作者
刘考强
元唯安
Liu Kaoqiang;Yuan Weian(Master Degree Student of Grade 2020,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Shi's Center of Orthopedics and Traumatology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)
出处
《国际中医中药杂志》
2022年第12期1347-1351,共5页
International Journal of Traditional Chinese Medicine
基金
国家自然科学基金项目(81403414)
上海市卫健委临床研究专项(201940063)
上海市“科技创新行动计划”生物医药科技支撑专项(20S21902100)
上海市卫计委“杏林新星”项目(ZYSNXD011-RC-XLXX-20130049)
“中西医结合-中成药临床评价平台项目(A1-U21-205-0103)
上海申康医院发展中心“市级医院医企协同临床试验管理项目”(20CR4003B)
上海申康医院发展中心临床三年行动计划项目(SHDC2020CR1051B)
上海市慢性筋骨病临床医学研究中心项目(20MC1920600)。
关键词
肌肉衰减征
脾肾虚衰
健脾补肾法
线粒体
炎症因子
Sarcopenia
Dual vacuity of the spleen and kidney
Invigorating spleen and tonifying kidney
Mitochondria
Inflammatory factor
