摘要
慢性丙型肝炎与高尿酸血症之间存在相互影响。作为一种全身性疾病,丙型肝炎病毒感染所引起的慢性丙型肝炎可导致代谢紊乱和肝肾功能受损,进而影响尿酸代谢;高尿酸水平可促进肝脏脂肪变性,从而加速慢性丙型肝炎进程。另外,丙型肝炎治疗已进入直接抗病毒药物时代,但抗病毒治疗对尿酸代谢的影响仍无定论。该文就近年来慢性丙型肝炎及其治疗和血尿酸水平的研究进展进行综述。
There is an interaction between chronic hepatitis C(CHC)and hyperuricemia.As a systematic disease,CHC,caused by hepatitis C virus(HCV),can lead to renal failure,liver dysfunction,and metabolic abnormality,which in turn affect uric acid metabolism,such as abnormal serum uric acid(SUA)level.Meanwhile,high SUA level can also promote hepatic steatosis,which accelerates the progression of CHC.Although direct-acting antiviral agents(DAAs)have been widely used for treating CHC patients,the effect of DAAs on uric acid metabolism is still unclear.In this article,we overview recent findings regarding the impact of DDA-treated CHC on SUA level.
作者
王悠扬
张冰清
张昀
曾学军
WANG Youyang;ZHANG Bingqing;ZHANG Yun;ZENG Xuejun(Department of Family Medicine&Division of General Internal Medicine,Department of Medicine,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,State Key Laboratory of Complex Severe and Rare Diseases(Peking Union Medical College Hospital),Beijing 100730,China;Medical Doctor Program,Chinese Academy of Medical Science&Peking Union Medical College,Beijing 100730,China)
出处
《医药导报》
CAS
北大核心
2023年第2期177-181,共5页
Herald of Medicine
基金
国家自然科学基金资助项目(81901667,82071841)
北京协和医学院2019年学科建设项目《全科医学人才培养项目》(201920200106)。
关键词
抗病毒药物
直接
丙型肝炎
慢性
尿酸
Antiviral drugs,direct-acting
Hepatitis C,chronic
Uric acid
