基于VOSviewer和CiteSpace的肿瘤凋亡及自噬研究领域的可视化分析

Visual analysis of tumor apoptosis and autophagy research based on VOSviewer and CiteSpace

目的分析肿瘤细胞凋亡和自噬研究领域的热点和发展趋势。方法通过Web of Science核心合集数据库检索2012年1月-2021年12月肿瘤凋亡和自噬的相关文献,应用CiteSpace 5.8.R3软件和VOSviewer version 1.6.10软件分析文献发文国家/地域、机构、关键词及引文节点信息。结果检索并筛选后纳入6716篇外文文献,论文发表数量随年代呈直线上升趋势。中国发文量最大、与其他研究机构合作紧密,但质量高且有影响力的文章不多;Autophagy和Cell这2个期刊在肿瘤凋亡与自噬研究领域中较为权威;凋亡和自噬的信号通路及相关蛋白、基于凋亡/自噬的肿瘤抑制机制研究是目前的研究热点主题,而癌细胞的迁移、凋亡和上皮细胞-间充质转化的研究是未来的研究热点和方向。结论近10年间,肿瘤凋亡和自噬的研究不断发展,随着对分子水平的深入研究,对其机制的研究有望进一步揭开肿瘤凋亡和自噬的奥秘。

Objective To analyze the hotspots and development trends in the research field of tumor cell apoptosis and autophagy.Methods Relevant literature on tumor apoptosis and autophagy published between January2012 and December 2021 were searched through the Web of Science core collection database,and CiteSpace 5.8.R3software and VOSviewer version 1.6.10 software were used to analyze the country/region,institution,keywords and citation node information of the literature.Results A total of 6716 foreign-language articles were included in the study after searching and screening,and the number of papers showed a linear upward trend year by year.China published the largest number of articles and cooperated closely with other research institutions,but there were not many high-quality and influential articles.The two journals Autophagy and Cell were more authoritative in the field of tumor apoptosis and autophagy research.The signaling pathways and related proteins of apoptosis and autophagy,and the study of tumor suppressor mechanisms based on apoptosis/autophagy were current research hot topics.The migration,apoptosis and epithelial mesenchymal transformation of cancer cells would be the research focus and direction in the future.Conclusions In the past 10 years,the research on tumor apoptosis and autophagy has continued to develop.With the in-depth research on the molecular level,the study of its mechanism is expected to further reveal the mystery of tumor apoptosis and autophagy.