2021年中国发布临床实践指南利益冲突与经济学证据的调查分析

Conflict of interest and economic evidence in Chinese clinical practice guidelines published in 2021:a survey

目的评价2021年中国发布的临床实践指南中利益冲突和经济学证据的情况,并与2017年和2018年发布的临床实践指南进行对比,充分了解中国指南制订变化情况,为进一步完善我国临床实践指南的制订提供参考。方法系统检索中国知网(CNKI)、中国生物医学文献数据库(CBM)和万方数据库(WanFang Data),搜索2021年1月1日至2021年12月31日我国发布的临床实践指南。由2名研究者独立进行文献筛选、提取纳入指南的利益冲突和是否考虑经济学证据等相关信息后,使用Microsoft Excel 2019软件进行统计分析。结果共纳入临床实践指南164部,其中112部(68.29%)声明了利益冲突,70部(42.68%)报告了资金来源,在临床实践指南推荐意见形成及治疗中考虑经济学证据的只有30部(18.29%),三方面同时报道的指南仅有16部(9.76%)。相较于2017年与2018年,2021年我国发布的临床实践指南在利益冲突声明和资金投入力度方面均有改善,但经济学证据关注仍然很低。结论建议进一步完善我国临床实践指南对利益冲突的声明和管理及对经济学证据的关注,使指南制订更加客观、透明和科学。

Objective To evaluate the situation of conflict of interest and economic evidence in Chinese clinical practice guidelines published in 2021,and compare with the relevant content guidelines published in 2017 and 2018.In order to find the changes in guidelines development and also provide implications for guidelines in China.Method CNKI,CBM and Wan Fang Data were searched to collect clinical practice guidelines in China published in 2021from January 1st to December 31st.Two researchers independently screened literature,extracted relevant information such as conflict of interest disclosure and economic evidences,then,the analysis was performed by using Microso?t Excel 2019 so?tware.Result A total of 164 clinical practice guidelines were finally included,in which 112(68.29%)declared conflict of interest,70(42.68%)reported sources of funding,30(18.29%)considered economic evidence,and only 16(9.76%)reported three aspects at the same time.Compared with the clinical practice guidelines published in 2017 and 2018 in China,the formulation of the guidelines has improved in terms of conflict of interest statements and funding,but the attention to economic evidence is still very low.Conclusion We should further improve the statement and management of conflict of interest and the attention to economic evidence in China?s clinical practice guidelines,which will make the guidelines more objective,transparent and scientific.