893例利巴韦林注射液临床不良反应分析

Analysis of 893 Cases of Adverse Drug Reactions in Clinical Practice Caused by Ribavirin Injection

目的:探究利巴韦林注射液不良反应的特点,为临床合理用药提供参考。方法:以患者性别、年龄、不良反应发生时间、过敏史、不良反应临床表现及转归等指标作为考查项,采用回顾性研究,对2010年5月-2022年9月河南省药品不良反应监测中心收集的893例利巴韦林注射液不良反应报告进行分析。结果:893例不良反应患者中,男女比例为1.31:1,发生时间主要集中在用药30 min以内(53.64%)。临床表现主要为全身性损害(26.78%)、皮肤及其附件损害(24.23%)、消化系统损害(23.76%)、神经系统损害(11.30%)等。结论:上述结果提示利巴韦林注射液可引起不同程度的不良反应,临床用药时应给予足够重视,确保合理用药,密切关注患者用药变化,加强不良反应监测,提高用药安全性。

Objective: To explore the characteristics of adverse drug reactions/events(ADR) of Ribavirin Injections and provide references for rational clinical medication. Methods: With patient’s gender, age,occurrence time of ADR, allergic history, clinical manifestations of ADR and outcome as the examination items,a retrospective study was performed to analyze 893 cases of ADR induced by Ribavirin Injection collected from Henan ADR Monitoring Center from May 2010 to September 2022. Results: The results indicated that among the 893 cases of ADR, the ratio of male to female was 1.31:1, the occurrence time of ADR cases mainly happened within 30 min(53.64%) of medication. The clinical manifestations were mainly affected systems included systemic lesion(26.78%), skin and appendages(24.23%), digestive system(23.76%), central and peripheral nervous systems(11.30%), etc. Conclusion: These results suggested that a variety of degrees of ADR can be induced by Ribavirin Injection, while enough attention should be paid to the clinical use of Ribavirin Injection. To ensure rational use of the drugs, more close attention must be paid to the changes in patient’s medication, ADR monitoring also should be strengthened to improve the safety of medication.