12例原发性尿道癌患者临床分析

Clinical analysis of 12 cases of primary urethral carcinoma

目的探讨原发性尿道癌的临床特点、诊断、治疗及预后。方法对北京医院在2016年7月至2020年12月期间收治的12例原发性尿道癌患者的临床资料及随诊资料进行回顾性分析。结果12例患者中男4例,女8例,平均年龄66.3(53~75)岁。9例患者术前接受磁共振检查,8例提示尿道异常信号,女性分期普遍晚于男性,所有患者均接受手术治疗。4例男性患者术后未予以其他辅助治疗,均为无瘤生存状态。8例女性,4例患者接受了术后的辅助放疗或化疗,5例随访期间出现了复发或转移,2例死亡。结论女性尿道癌检出时相对于男性的临床分期更晚,MRI检查有益于尿道癌局部浸润情况的判定,对于女性近端尿道癌和男性后尿道癌,根治性切除手术具有较好的疗效。

Objective To investigate the clinical features,diagnosis,treatment and prognosis of primary urethral carcinoma.Methods The clinical and follow-up data of 12 patients with primary urethral carcinoma admitted to Beijing Hospital from July 2016 to December 2020 were retrospectively analyzed.Results There were four males and eight females,with an average age of 66.3(53~75)years.Nine patients underwent magnetic resonance examination before operation,and eight patients presented with abnormal urethral signals.The clinical stage of female patients was generally later than those of male patients,and all patients received surgical treatment.Four male patients did not receive post-operative adjuvant treatment,and all of them attained disease-free survival.Among the eight female patients,four patients received postoperative adjuvant radiotherapy or chemotherapy,five patients had recurrence or metastasis during follow-up,and two patients died.Conclusions The clinical stage of female urethral cancer is later than that of male.MRI examination is beneficial to the determination of local invasion of urethral cancer.For female proximal urethral cancer and male posterior urethral cancer,radical resection has a good therapeutic effect.