血浆TGF-β1与HER2阳性型左侧乳腺癌放化疗后心肌损伤的相关性

Correlation between plasma TGF-β1 and myocardial injury after radiochemotherapy for HER2-positive left breast cancer

目的 探究血浆转化生长因子-β1(TGF-β1)与表皮生长因子受体2(HER2)阳性型左侧乳腺癌放化疗后心肌损伤的相关性。方法 选取2019年2月至2022年3月于首都医科大学附属北京世纪坛医院HER2阳性型左侧乳腺癌放化疗后患者200例,其中49例心肌损伤患者为损伤组,151例心肌未损伤为未损伤组。收集两组患者相关资料;检测患者血浆TGF-β1、心肌钙蛋白T(cTnT)、肌酸激酶同工酶(CK-MB)水平。并分析HER2阳性型左侧乳腺癌放化疗后心肌损伤的相关因素。结果 两组一般资料比较,诊断时T、N分期、Ki67指数、HR状态比较差异无统计学意义(P>0.05),但两组肿瘤浸润淋巴细胞表达、组织学分级比较差异均具有统计学意义(P<0.05);损伤组血浆TGF-β1、cTnT、CK-MB水平高于未损伤组,差异具有统计学意义(P<0.05);血浆TGF-β1水平、肿瘤浸润淋巴细胞表达、组织学分级与HER2阳性左侧乳腺癌放化疗后心肌损伤的独立影响因素(P<0.05)。结论 血浆TGF-β1水平与肿瘤浸润淋巴细胞表达、组织学分级均是HER2阳性型左侧乳腺癌放化疗后心肌损伤的独立影响因素,血浆TGF-β1或可作为HER2阳性型左侧乳腺癌放化疗后心肌损伤的生物标志物,值得临床重视。

Objective To investigate the correlation between plasma transforming growth factor(TGF)-β1 and myocardial injury after radiochemotherapy for human epidermal growth factor receptor 2(HER2)positive left breast cancer. Methods A total of 200 patients with HER2-positive left breast cancer who underwent radiochemotherapy in Beijing Shijitan Hospital,Capital Medical University from February 2019to March 2022 were selected,including 49 patients with myocardial injury and 151 patients without. The relevant data of the two groups were collected. Plasma levels of TGF-β1,cardiac troponin T(cTnT)and creatine kinase isoenzyme(CK-MB)were detected. The factors related to myocardial injury after radiochemotherapy for HER2-positive left breast cancer were analyzed. Results There was no statistically significant difference in T staging,N staging,Ki67 index or HR between the two groups(P>0.05). However,the expression of tumor infiltrating lymphocytes and histological grade were significantly different between the two groups(P<0.05). The levels of plasma TGF-β1,cTnT and CK-MB in the injury group were higher than those in the non-injury group(P<0.05). Plasma TGF-β1 level,expression of tumor infiltrating lymphocytes,and histological grade were independent influencing factors of myocardial injury after radiochemotherapy for HER2-positive left breast cancer (P<0.05). Conclusion Plasma TGF-β1 level,expression of tumor infiltrating lymphocytes,and histological grade are independent influencing factors of myocardial injury after radiochemotherapy for HER2-positive left breast cancer. Plasma TGF-β1 may be a biomarker of myocardial injury after radiochemotherapy for HER2-positive left breast cancer,which is worthy of clinical attention.