中药镇静催眠作用机制的研究进展

Research progress on mechanism of sedative and hypnotic effects of traditional Chinese medicine

失眠是一种由多种因素导致的常见睡眠障碍性疾病。目前治疗失眠的方法多种多样,其中化学药治疗失眠存在诸多不良反应。中药在治疗疾病方面,可以通过多成分、多靶点之间相互的协同作用,减轻单一成分产生的不良反应,具有更好的安全性和疗效,被广泛应用于治疗失眠。基于中医药理论结合失眠的发病机制,对近年来具有镇静催眠作用的单味中药及中药复方作用机制加以梳理概括,为临床失眠的治疗用药提供参考。

Insomnia is a common sleep disorder caused by many factors. At present, there are various methods for treating insomnia,among which there are many adverse reactions in the treatment of insomnia with chemical medicine. Traditional Chinese medicine is widely used in the treatment of insomnia as it can reduce the adverse effects produced by a single ingredient through the synergistic effects between multiple ingredients and targets, and has better safety and efficacy. Based on the theory of traditional Chinese medicine and the pathogenesis of insomnia, the mechanism of action of single herb and compound prescription of traditional Chinese medicine with sedative and hypnotic effects in recent years were summarized to provide reference for the clinical treatment of insomnia.