中药治疗犬慢性心力衰竭研究进展

Application of traditional Chinese medicine in the treatment of chronic heart failure in dogs

慢性心力衰竭(CHF)是心血管疾病最重要的死亡原因,随着宠物步入老龄化、肥胖化,患有CHF的宠物愈发增多,在临床中犬最为突出。西兽医对CHF的治疗一般需长期用药,对肝肾的损伤较大。相较而言,中医辨证论治和整体观念具有天然优势。犬CHF的病因病机分为心气虚、气血瘀滞、心阳虚、肾阳虚和肾阴虚等。单味中药和复方中药均对犬CHF疗效明显,常用的单味中药主要有人参、附子、白芍和黄芪等;中药复方大多是以单味中药为基础的经方,并进行临床试验研究。本文从犬CHF病因病机、中药药理作用、临床实践等方面进行探讨,为犬CHF的治疗和新型中药制剂研发提供参考。

Chronic heart failure(CHF) is the most important cause of death of cardiovascular disease. With the gradual aging and obesity of pets in China, more and more pets suffer from CHF, especially dogs. The treatment of CHF by western veterinarians generally requires long-term medication, which will cause great damage to the liver and kidney. TCM treatment based on syndrome differentiation and holistic concept have natural advantages. Combined with clinical practice and literature analysis, it was found that the etiology and pathogenesis of canine CHF were divided into heart Qi deficiency, blood stasis, heart Yang deficiency, kidney Yang deficiency and kidney Yin deficiency. Both single Chinese medicine and compound Chinese medicine have obvious therapeutic effects on canine CHF. This article discussed the etiology and pathogenesis of canine CHF, the pharmacological effects of traditional Chinese medicine, and clinical practice, which could provide a reference for the clinical treatment of canine CHF and the development of new traditional Chinese medicine preparations.