水痘继发肝功能异常的临床特点

Retrospective analysis of clinical features of liver dysfunction associated with varicella-zoster virus infection

目的 分析水痘继发肝功能异常的临床特点及预后。方法 收集2010年1月至2022年1月联勤保障部队第九八八医院收治的330例水痘患者的临床资料,分析水痘继发肝功能异常者的临床特点。结果 68例(20.6%)患者出现肝功能异常,多发于成年人急性发病期,无明显临床不适症状,主要表现为ALT和AST轻度升高,以ALT升高更明显;ALT <100 U/L者一般不使用药物进行干预,ALT>100 U/L适当给予口服保肝药物,所有肝功能异常患者均可痊愈并不再出现反复。结论 肝功能异常是水痘较常见的并发症,其临床症状不明显,多表现为肝功能轻度损伤,经适当保肝治疗可痊愈。

Objective To analyze the clinical characteristics and prognosis of abnormal liver function secondary to varicella(chickenpox), so as to provide clinical decision support. Methods The clinical data of the 330 patients with varicella who were treated in our hospital from January 2010 to January 2022 were collected, and the clinical characteristics of the patients with abnormal liver function secondary to varicella were analyzed. Results Liver injury occurred in 68 patients, with an incidence rate of 20.6%. The majority of cases were in the acute stage of varicella infection without obvious clinical symptoms. The main manifestations were mild elevation of alanine aminotransferase(ALT) and aspartate aminotransferase(AST), in which the changes of ALT levels were more obvious. Patients with ALT <100 U/L generally did not use drug intervention, while patients with ALT>100 U/L received oral liver-protective drugs, all patients with abnormal liver function were cured and no recurrence was observed. Conclusion Although the prevalence of liver function abnormalities is common in patients with varicella, its clinical symptoms, mainly characterized by mild liver damage, are not obvious and could be cured by appropriate liver protection treatment.