基于半导体制冷的器官灌注保存箱的设计研究

Design and Research of Organ Perfusion Preservation Box Based on Semiconductor Refrigeration

针对器官低温灌注保存箱在长距离转运过程中存在温度升高问题,本文采用半导体制冷片设计了一款器官低温灌注保存箱,建立了保存箱基本模型并介绍了灌注系统工作原理,根据箱体构造计算了保存箱热负荷,选定半导体制冷片型号并对箱体测温点进行布置。在25℃环境温度,11.6 V供电电压下对保存箱进行了空载及装载离体猪肾的低温灌注保存实验。实验结果表明,半导体制冷装置开启后,箱内温度分别在143 min、236 min后稳定在4~8℃。保存箱内部温度处于合适温度区间,符合器官转运过程对温度的要求。

In order to solve the problem of temperature rise in the process of long-distance transport of organ low-temperature perfusion preservation box,a low-temperature perfusion preservation box of organ was designed by using semiconductor refrigerator.The basic model of the box was established and the working principle of the perfusion system was introduced.The heating load of the storage box was calculated by the structure of the box,chose the type of semiconductor refrigeration chip and arranged the box temperature measuring points.The cryopreservation experiments of no-load and isolated porcine kidney were carried out under the ambient temperature of 25℃and the supply voltage of 11.6 V.The experimental results show that after the semiconductor refrigeration system is turned on,the temperature in the box is stable at 4-8℃after 143 min and 236 min,respectively.The internal temperature of the storage box is in a suitable temperature range,which meets the temperature requirements of the organ transport process.