桃红四物汤治疗脑出血患者下肢深静脉血栓形成

Taohong Siwu decoction in the treatment of lower extremity deep vein thrombosis in patients with cerebral hemorrhage

目的探讨脑出血患者下肢深静脉血栓形成治疗中D-二聚体(D-dimer,DD)水平监测联合桃红四物汤治疗的价值。方法选取2021年7月至2022年5月湖州师范学院附属第一医院脑出血下肢深静脉血栓形成患者100例,分为单独低分子肝素钠治疗组(单独治疗组,2021年7月至2021年12月)、低分子肝素钠治疗基础上D-二聚体水平监测联合桃红四物汤治疗组(联合治疗组,2022年1月至2022年5月)两组,每组各50例,分析两组凝血功能指标、血液流变学指标、血栓弹力图、临床疗效、下肢深静脉血栓形成发生情况。结果联合治疗组患者的D-D水平低于单独治疗组(P<0.05),纤维蛋白原(fibrinogen,FIB)水平低于单独治疗组(P<0.05),凝血酶原时间(prothrombin time,PT)长于单独治疗组(P<0.05),部分凝血活酶时间(activated partial thromboplastin time,APTT)长于单独治疗组(P<0.05),全血低切黏度低于单独治疗组(P<0.05),全血中切黏度低于单独治疗组(P<0.05),全血高切黏度低于单独治疗组(P<0.05),血浆黏度低于单独治疗组(P<0.05),R值、K值均高于单独治疗组(P<0.05),MA值、α角度均低于单独治疗组(P<0.05),联合治疗组总有效率98.00%(49/50)高于单独治疗组72.00%(36/50)(χ^(2)=13.255,P<0.05),下肢深静脉血栓形成发生率为4.00%(2/50),低于单独治疗组20.00%(10/50)(χ^(2)=6.061,P<0.05)。结论脑出血患者下肢深静脉血栓形成治疗中DD水平监测联合桃红四物汤治疗的价值较高。

Objective To explore the value of D-dimer level monitoring combined with Taohong siwu decoction in the treatment of patients with deep vein thrombosis of lower extremity andcerebral hemorrhage.Methods A total of 100 patients with cerebral hemorrhage and lower extremity deep vein thrombosis in the First People's Hospital of Huzhou,the First Affiliated Hospital of Huzhou Normal University from July 2021 to May 2022 were selected and divided into low molecular weight heparin sodium alone treatment group(single treatment group,July 2021 to December 2021),low molecular weight heparin sodium treatment group on the basis of heparin sodium treatment,D-dimer level monitoring combined with Taohong Siwu decoction treatment group(combination treatment group,from January 2022 to May 2022),50 cases in each group.The coagulation function indexes,hemorheology indexes,thromboelastography,clinical efficacy,and deep veins thrombosis occurs of lower extremities in the two groups were statistically analyzed.Results The(D-dimer,DD)level of the combined treatment group was lower than single treatment group(P<0.05),the FIB level was lower than single treatment group(P<0.05),the(Prothrombin time,PT)was longer than single treatment group(P<0.05),and the(activated partial thromboplastin time,APTT)was longer than single treatment group(P<0.05).the whole blood low shear viscosity was lower than single treatment group(P<0.05),the whole blood middle shear viscosity was lower than single treatment group(P<0.05),the whole blood high shear viscosity was lower than single treatment group(P<0.05),the plasma viscosity was lower than single treatment group(P<0.05),the R value and K value were higher than those of the single treatment group(P<0.05),and the MA value andαangle were lower than those of the single treatment group(P<0.05).The efficiency was 98.00%(49/50)in combination treatment group higher than 72.00%(36/50)in than single treatment group(χ^(2)=13.255,P<0.05),and the incidence of deep vein thrombosis of the lower extremities was 4.00%(2/50)lower 20.00%(10/50) (χ^(2)=6.061, P<0.05). Conclusion The value of D-dimer level monitoring combined with Taohong Siwu decoction in the treatment of patients with cerebral hemorrhage is high and lower extremity deep vein thrombosis.