摘要
原花青素是广泛存在于多种植物中的重要天然生物活性物质。近年来的研究表明,动物饲粮中添加不同来源的原花青素能够调节肠道菌群的多样性与组成,并通过菌群及其代谢产物与肠黏膜免疫系统发生相互作用,从而调节肠道免疫应答。本文综述了原花青素对菌群及其代谢产物的塑造作用,总结了原花青素对肠道免疫应答的调节及可能的作用机制,为原花青素在改善动物肠道健康方面的基础研究和生产应用提供参考依据。
Proanthocyanidins(PACs)are important natural biologically active substances that are widely existing in various plants.Recent studies have shown that the addition of PACs from different sources in animal diets can regulate the diversity and composition of intestinal microbiota,and interact with the intestinal mucosal immune system through the microbiota and their metabolites to regulate the intestinal immune response.This paper reviewed the role of PACs played in shaping intestinal microbiota and their metabolites,and summarized the regulation of PACs on intestinal immune response and possible mechanisms,providing a reference for the basic research and application of PACs in improving animal intestinal health.
作者
苏玲玲
黎小银
易宏波
高彦华
SU Lingling;LI Xiaoyin;YI Hongbo;GAO Yanhua(Key Laboratory of Animal Science School of National Ethnic Affairs Commission of China,Key Laboratory of Qinghai-Tibet Plateau Animal Genetic Resources Conservation and Utilization,College of Animal and Veterinary Sciences,Southwest Minzu University,Chengdu 610041,China;Guangdong Key Laboratory of Animal Breeding and Nutrition,Key Laboratory of Animal Nutrition and Feed Science in South China,Ministry of Agriculture and Rural Affairs,State Key Laboratory of Livestock and Poultry Breeding,Institute of Animal Science,Guangdong Academy of Agricultural Sciences,Guangzhou 510640,China)
出处
《动物营养学报》
CAS
CSCD
北大核心
2023年第3期1454-1467,共14页
CHINESE JOURNAL OF ANIMAL NUTRITION
基金
中央高校基本科研业务费专项资金项目(ZYN2022106)
四川省自然科学基金项目(2023NSFSC1148)。
关键词
原花青素
肠道
菌群
代谢
免疫应答
proanthocyanidins
intestine
microbiota
metabolism
immune response
