铁死亡与免疫细胞关系的研究进展

Research progress on the relationship between ferroptosis and immune cells

铁死亡(Ferroptosis)是一种铁依赖的新型细胞程序性死亡方式,其特征是活性氧(reactive oxygen species,ROS)和脂质过氧化的过量蓄积。铁死亡在免疫调节方面作用的研究越来越多,而免疫细胞是机体免疫系统最重要的一环,本文阐述铁死亡与免疫细胞关系的研究进展,首先阐明铁死亡核心靶点谷胱甘肽过氧化物酶4(glutathione peroxidase 4,Gpx4)在各种免疫细胞增殖和免疫反应中的作用,其次总结细胞发生铁死亡能释放包括损伤相关分子模式(damage associated molecular patterns,DAMPs)等多种分子,这些分子能影响免疫细胞的分化与功能,进而影响疾病的发生和进展。同时,免疫细胞分泌免疫因子或其代谢物也能影响细胞铁死亡的发生。最后,我们对未来的研究进行了简要的总结和展望,这将有助于指导疾病治疗方向。

Ferroptosis is novel iron-dependent programmed cell death characterized by excessive accumulation of reactive oxygen species and lipid peroxidation.In recent years,an increasing number of studies have focused on the roles of immunomodulation in ferroptosis.Immune cells are the most important part of the immune system.This review discusses the current research progress on the relationship between ferroptosis and immune cells.The role of glutathione peroxidase 4(Gpx4)in immune cell proliferation and the immune response is summarized.Ferroptosis releases various molecules including damage-associated molecular patterns,which influences the differentiation and function of immune cells and thereby affects disease progression.Moreover,immune factors or their metabolites secreted by immune cells affect the occurrence of ferroptosis.This review concludes with a brief summary and outlook for future research,which may be helpful to guide the direction of disease treatment.