氨溴索支气管肺泡灌洗治疗支气管扩张合并感染的临床效果

Clinical Effect of Ambroxol on Pulmonary Function in Bronchoalveolar Lavage for Bronchiectasis and Infection

目的浅析支气管肺泡灌洗治疗支气管扩张并感染应用氨溴索对肺功能的影响。方法选取2019年10月—2021年2月荣成市人民医院支气管扩张并感染患者72例,随机分为观察组(氨溴索支气管肺泡灌洗)和对照组(常规治疗),各36例,比较两组患者的临床疗效、肺功能及炎性因子水平。结果观察组患者治疗有效率为94.44%,高于对照组的77.78%(P<0.05)。观察组患者的呼气峰值流速(peak expiratory flow,PEF)及用力肺活量(forced vital capacity,FVC)、第1秒用力呼气容积(forced expiratory volume in one second,FEV_(1))等各项指标分别为(4.69±0.72)L/s、(2.59±0.38)L以及(1.72±0.31)L明显高于对照组(4.21±1.29)L/s、(2.09±0.58)L以及(1.49±0.18)L(P<0.05)。同时观察组可溶性尿激酶型纤溶酶原激活物受体(soluble urokinase plasminogen activator receptor,suPAR)、可溶性髓系细胞触发受体-1(soluble triggering receptor expressed on myeloid cells-l,sTREM-1)、C反应蛋白(C-reactive protein,CRP)、肿瘤坏死因子-α(tumor necrosis factorα,TNF-α)指标分别为(5.09±0.98)ng/mL、(39.82±4.47)pg/mL、(11.21±2.18)mg/L及(13.61±2.31)pg/mL均低于对照组(5.78±1.13)ng/mL、(46.57±5.68)pg/mL、(17.54±3.21)mg/L及(24.65±3.64)pg/mL,差异有统计学意义(P<0.05)。结论氨溴索支气管肺泡灌洗治疗支气管扩张并感染的疗效十分显著,是一种安全、有效的治疗方法,建议在临床上予以推广。

Objective To explore the effect of bronchoalveolar lavage plus ambroxine on lung function in patients with bronchiectasis and infection.Methods A total of 72 patients with bronchiectasis and infection in Rongcheng People's Hospital from October 2019 to February 2021 were selected,and were randomLy divided into the observation group(bronchoalveolar lavage with ambroxol)and the control group(routine treatment)with 36 cases each.The clinical efficacy,pulmonary function and inflammatory factor level of the two groups were compared.Results The effective rate of treatment in the observation group was 94.44%higher than that in the control group(77.78%)(P<0.05).The indexes of PEF,FVC and FEV_(1) in the observation group were(4.69±0.72)L/s,(2.59±0.38)L and(1.72±0.31)L respectively,which were significantly higher than those in the control group(4.21±1.29)L/s,(2.09±0.58)L and(1.49±0.18)L(P<0.05).At the same time,suPAR,sTREM-1,CRP and TNF in the observation group-αThe indexes of(5.09±0.98)ng/mL,(39.82±4.47)pg/mL,(11.21±2.18)mg/L and(13.61±2.31)pg/mL in the control group were lower than those of(5.78±1.13)ng/mL,(46.57±5.68)pg/mL,(17.54±3.21)mg/L and(24.65±3.64)pg/mL in the control group,respectively(P<0.05).Conclusion Ambromine bronchoalveolar lavage is a safe and effective treatment for bronchiectasis and infection,and it is recommended to be popularized in clinical practice.