促性腺激素释放激素拮抗剂在辅助生殖的应用及优劣研究进展

Application of gonadotropin-releasing hormone antagonists in assisted reproduction and research progress of their advantages and disadvantages

促性腺激素释放激素拮抗剂(GnRH-A)通过竞争性结合促性腺激素释放激素(GnRH)受体,直接抑制促性腺激素(Gn)分泌。拮抗剂可单次或多次给药,在临床中更是探索出了许多应用方案,如联合氯米芬、芳香化酶抑制剂或人绝经期促性腺激素等。拮抗剂方案因减少卵巢过度刺激综合征发生、减少促性腺激素用量、适应人群广等诸多优点受到广泛应用,但其可能导致在新鲜周期移植中的妊娠率偏低。本文旨在阐述拮抗剂在辅助生殖应用中的应用及研究进展。

Gonadotropin releasing hormone antagonist(GnRH-A)directly inhibits gonadotropin(Gn)secretion by binding to gonadotropin releasing hormone(GnRH)receptor competitively.Antagonists can be administered once or many times.Many clinical applications have been explored.Antagonists can combine with clomiphene,aromatase inhibitor or human menopausal gonadotropin and so on.Antagonist has been widely used because of its advantages such as reducing the occurrence of ovarian hyperstimulation syndrome,reducing the dosage of gonadotropin,and being suitable for a wide population.However it may lead to a low pregnancy rate in fresh cycle transplantation.This article aims to review the application and research progress of antagonists in assisted reproduction.