妊娠合并系统性红斑狼疮患者子代远期发育结局的研究进展

Research progress on long-term developmental outcomes of offspring of pregnant women with systemic lupus erythematosus

系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种累及多器官多系统的自身免疫性结缔组织病,好发于女性育龄期。与一般人群相比,妊娠合并SLE患者发生早产、宫内生长受限等不良围生期结局的风险明显增加。另外,SLE患者的子代在宫内暴露于母体自身抗体、细胞因子和药物等,也可能对子代的远期发育造成不利影响。该文从血液系统、循环系统、神经系统、免疫系统等方面对妊娠合并SLE患者子代的远期发育结局予以总结。

Systemic lupus erythematosus(SLE)is an autoimmune connective tissue disease that affects multiple organs and systems.It is more common in women of childbearing age.Compared with the general population,pregnant women with SLE are at a significantly increased risk of adverse perinatal outcomes such as preterm birth and intrauterine growth restriction.In addition,the offspring of SLE patients may also be adversely affected by in utero exposure to maternal autoantibodies,cytokines,and drugs.This article summarizes the long-term developmental outcomes of offspring of pregnant women with SLE in terms of the blood system,circulatory system,nervous system,and immune system.