鼻渊舒汤联合盐酸西替利嗪滴剂治疗儿童过敏性鼻炎风热犯肺证临床研究

Clinical Study on Biyuanshu Decoction Combined with Cetirizine Hydrochloride Drops for Allergic Rhinitis in Children with Wind-Heat Invading the Lung Syndrome

目的:观察鼻渊舒汤联合盐酸西替利嗪滴剂治疗儿童过敏性鼻炎(AR)风热犯肺证的临床疗效。方法:选择90例AR风热犯肺证患儿,按随机数字表法分为对照组和治疗组各45例。对照组给予盐酸西替利嗪滴剂治疗,治疗组在对照组基础上给予鼻渊舒汤治疗,2组均治疗2周。比较2组临床疗效、临床症状缓解时间,以及治疗前后症状、体征评分与血清白细胞介素-5(IL-5)、白细胞介素-8(IL-8)、可溶性细胞间黏附分子-1(sICAM-1)水平。结果:治疗后,治疗组临床疗效总有效率95.56%,高于对照组82.22%(P<0.05)。治疗后,2组症状、体征评分均较治疗前降低(P<0.05),治疗组症状、体征评分低于对照组(P<0.05)。治疗组鼻塞、鼻痒、流鼻涕、打喷嚏缓解时间均短于对照组(P<0.05)。治疗后,2组血清IL-5、IL-8、sICAM-1水平均较治疗前降低(P<0.05),治疗组血清IL-5、IL-8、sICAM-1水平均低于对照组(P<0.05)。结论:鼻渊舒汤联合盐酸西替利嗪滴剂治疗儿童AR风热犯肺证疗效确切,可促进患儿临床症状及体征改善,有效减轻炎症反应。

Objective:To observe the clinical effect of Biyuanshu Decoction combined with Cetirizine Hydrochloride Drops for allergic rhinitis(AR) in children with wind-heat invading the lung syndrome.Methods:A total of 90 cases of AR children with wind-heat invading the lung syndrome were divided into the control group and the treatment group according to the random number table method,with 45 cases in each group. The control group was treated with Cetirizine Hydrochloride Drops,and the treatment group was additionally treated with Biyuanshu Decoction based on the treatment of the control group. Both groups were treated for 2 weeks. The scores of symptoms and signs and the levels of interleukin-5(IL-5),interleukin-6(IL-6) and soluble intercellular adhesion molecule-1(sICAM-1) in serum before and after treatment, as well as the clinical effects and the remission time of clinical symptoms were compared between the two groups. Results:After treatment,the total effective rate of clinical effect was 95.56% in the treatment group, higher than that of 82.22% in the control group(P<0.05). After treatment, the scores of symptoms and signs in the two groups were decreased when compared with those before treatment(P<0.05),the score of symptoms and signs in the treatment group was lower than that in the control group(P<0.05). The remission time of nasal obstruction,nasal itching,runny nose,and sneezing in the treatment group was shorter than that in the control group(P<0.05). After treatment,the levels of IL-5,IL-8 and sICAM-1 in serum in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of IL-5,IL-8 and sICAM-1 in serum in the treatment group were lower than those in the control group(P<0.05). Conclusion:Biyuanshu Decoction combined with Cetirizine Hydrochloride Drops has a definite curative effect in treating AR children with wind-heat invading the lung syndrome,which can promote the improvement of clinical symptoms and signs in children,and effectively relieve inflammatory responses.