摘要
钙粘蛋白(cadherin,CDH)5,又称血管内皮细胞CDH(vascular endothelial cell-CDH,VE-CDH),是一种内皮细胞特异性膜蛋白。CDH5可促进微血管生成,为肿瘤细胞提供适合的支持微环境,并能促进肿瘤细胞增殖和转移。CDH5与恶性肿瘤发生、发展的各个过程都有密切关系。文章总结了CDH5在多种肿瘤中的研究现状,评估CDH5在促进肿瘤细胞生成、转移及预后的潜力。
Cadherin(CDH)5,also known as vascular endothelial cell CDH(VE-CDH),is an endothelial cell-specific membrane protein.CDH5 can promote angiogenesis,provide a suitable supporting microenvironment for tumor cells,and promote tumor cell proliferation and metastasis.CDH5 is closely related to the occurrence and development of malignant tumors.This review summarizes the research status of CDH5 in various malignant tumors,and to evaluate the potential of CDH5 in promoting tumor cell generation,metastasis and prognosis.
作者
张星海
方天逸
边秀兰
张磊
Zhang Xinghai;Fang Tianyi;Bian Xiulan;Zhang Lei(Department of Pathology,Harbin Medical University,Harbin 150081,China;Department of Gastroenterological Surgery,Harbin Medical University Cancer Hospital,Harbin Medical University,Harbin 150081,China)
出处
《国际免疫学杂志》
CAS
2023年第1期66-70,共5页
International Journal of Immunology
关键词
钙粘蛋白5
恶性肿瘤
增殖
转移
预后评估
Cadherin5
Malignant tumor
Proliferation
Metastasis
Prognostic evaluation
