《伤寒杂病论》中干姜的量效关系及配伍规律

Dose-effect Relationship and Compatibility Rules of Zingiberis Rhizoma in Treatise on Cold Damage and Miscellaneous Diseases

目的:探讨干姜在《伤寒杂病论》中的量效关系以及配伍用药规律。方法:整理出《伤寒论》《金匮要略》中含有干姜的条文,采用SPSS 19.0统计软件单因素逻辑回归分析、二元相关性分析以及独立样本t检验分析干姜剂量与其相关因素之间的关系,并且总结干姜量效特点及其主治证候。结果:经筛选共纳入含干姜方剂42首,占《伤寒杂病论》全部方剂比例的16.28%,对其中可进行统计学分析的30方剂分析发现,干姜单次用量与药味数量、剂量、服用次数均有相关性。单因素逻辑回归分析表明,干姜的单次用量、药味数量、用水量、剩余水量、单次服用水量、服用次数和干姜在组方中是否作为主药并无相关性;与其作为非主药比较,干姜与附子、细辛、人参、配伍时作为主药的单次用量差异明显。结论:通过对其量效关系的研究可以发现,干姜在临床上的使用及其疗效主要通过与其他药物配伍实现,与附子配伍时用量为13~28 g,与细辛配伍时用量为4~6 g,与人参配伍时用量为6~16 g,(表6得出为6~16 g)并得出干姜可作为固定剂量应用于临床,所得剂量为6~35 g。干姜的作用部位主要在中焦,以温中为主,通过温中,散寒邪在胸中,治寒邪在筋骨者,治寒邪在肠胃者。

Objective:To explore the dose-effect relationship and compatibility rules of Zingiberis Rhizoma in Treatise on Cold Damage and Miscellaneous Diseases.Methods:The articles containing Zingiberis Rhizoma in Treatise on Cold Damage and Essentials from the Golden Cabinet were sorted out,and SPSS19.0 statistical software was used for single factor logistic regression analysis,binary correlation analysis,and independent sample t-test to analyze the difference between the dose of Zingiberis Rhizoma and its related factors.The dose-effect characteristics of Zingiberis Rhizoma and its indications were summarized.Results:After the screening,42 prescriptions containing Zingiberis Rhizoma were included,accounting for 16.28%of all prescriptions in Treatise on Cold Damage and Miscellaneous Diseases.The analysis of 31 prescriptions that could be statistically analyzed found that the single dose of Zingiberis Rhizoma and the quantity and dosage of the medicine and the number of takings were all related.Single-factor logistic regression analysis showed that the single dose of Zingiberis Rhizoma,the amount of medicinal flavor,the amount of water,the remaining amount of water,the single dose of water,the number of doses,and whether Zingiberis Rhizoma was used as the main drug in the prescription were not correlated.The single dosage of Zingiberis Rhizoma when it was not the main drug was different from that of Zingiberis Rhizoma as the main drug and was compatible with Aconiti Lateralis Radix Praeparata,Asari Radix et Rhizoma,and Ginseng Radix et Rhizoma.Conclusion:Through the study of its dose-effect relationship,it can be found that the clinical use and curative effect of Zingiberis Rhizoma are mainly achieved through compatibility with other drugs.The dosage is 13~28 g when Zingiberis Rhizoma is compatible with Aconiti Lateralis Radix Praeparata,4~6 g when it is compatible with Asari Radix et Rhizoma,and 6~16 g when it is compatible with Ginseng Radix et Rhizoma.It is concluded that Zingiberis Rhizoma can be used as a fixed dose in the clinic,and the resulting dosage is 6~35 g.The acting part of Zingiberis Rhizoma is mainly the middle-energizer,with the main effect of warming the middle.By warming the middle,cold pathogens in the chest can be dispelled,and cold pathogens in the bones,stomach,and intestines can be cured.