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益气养阴活血汤辅助治疗对肾病综合征患儿TIMP-2、T淋巴细胞亚群及IL-8影响 被引量:1

Effect of adjuvant therapy of Yiqi Yangyin Huoxue Decoction on TIMP-2,T lymphocyte subsets and IL-8 in children with nephrotic syndrome
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摘要 目的分析益气养阴活血汤辅助治疗对肾病综合征患儿金属蛋白酶组织抑制因子-2(TIMP-2)、T淋巴细胞亚群及白细胞介素-8(IL-8)水平影响。方法选取2019年1月至2021年1月河南中医药大学第一附属医院收治的102例肾病综合征患儿临床资料,根据治疗方式不同分为对照组(西医常规)47例与观察组(西医常规联合益气养阴活血汤)55例。均治疗4个疗程。对比临床疗效、中医症状积分、TIMP-2、T淋巴细胞亚群、IL-8水平、肾功能[血清肌酐(SCr)、血尿素氮(BUN)、24小时尿蛋白定量(24hUTP)]、不良反应。结果观察组治疗后总有效率占比为96.36%,明显高于对照组的82.67%,差异有统计学意义(P<0.05)。观察组治疗后中医症状积分各项目评分低于对照组,差异有统计学意义(P<0.05)。治疗后观察组CD8^(+)、TIMP-2、IL-8水平均低于对照组,CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平则高于对照组,差异有统计学意义(P<0.05)。观察组SCr、BUN、24hUTP值均低于对照组,差异有统计学意义(P<0.05);两组不良反应比较差异无统计学意义(P>0.05)。结论益气养阴活血汤辅助治疗肾病综合征临床疗效显著,可有效改善患者TIMP-2、T淋巴细胞亚群及IL-8水平,缓解患者临床症状,安全性尚可。 Objective To analyze the effects of Yiqi Yangyin Huoxue Decoction adjuvant therapy on serum tissue inhibitor of metalloproteinase-2(TIMP-2),T lymphocyte subsets and interleukin-8(IL-8)levels in children with nephrotic syndrome.Methods The clinical data of 102 children with nephrotic syndrome admitted to our hospital from January 2019 to January 2021 were selected,and according to different treatment methods,the patients were divided into the control group(western medicine treatment)of 47 cases and the observation group(Traditional Western Medicine Combined with Yiqi Yangyin Huoxue Decoction)of 55 cases.The two groups received 4 courses of treatment.The clinical curative effect,TCM symptom score,TIMP-2,T lymphocyte subsets,IL-8 level,renal function[serum creatinine(SCr),blood urea nitrogen(BUN),24-hour urinary protein(24hUTP)]and adverse reactions were compared between the two groups after treatment.Results The total effective rate in the observation group after treatment was 96.36%,which was significantly higher than that in the control group(82.67%),and the difference is statistically significant(P<0.05).After treatment,the scores of TCM symptom scores in the observation group were lower than those in the control group,and the difference is statistically significant(P<0.05).After treatment,the levels of CD8^(+),TIMP-2,IL-8 in the observation group were lower than those in the control group,while the levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)in the observation group were higher than those in the control group,and the difference is statistically significant(P<0.05).The values of SCR,BUN and 24h UTP in the observation group were lower than those in the control group,and the difference is statistically significant(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion Yiqi Yangyin Huoxue Decoction has a significant clinical curative effect in the adjuvant treatment of nephrotic syndrome,can effectively improve the levels of TIMP-2,T lymphocyte subsets and IL-8 in patients,and relieve the clinical symptoms of patients,with acceptable safety.
作者 梁上艳 黄书丽 吴静静 王纪云 刘媛媛 柴树伟 魏明杰 李灿灿 LIANG Shangyan;HUANG Shuli;WU Jingjing;WANG Jiyun;LIU Yuanyuan;CHAI Shuwei;WEI Mingjie;LI Cancan(The Sixth District Department of Pediatrics,the First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou,Henan,China,450000;Department of Pediatrics,the First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou,Henan,China,450000)
出处 《分子诊断与治疗杂志》 2023年第4期564-567,572,共5页 Journal of Molecular Diagnostics and Therapy
基金 河南省中医药科学研究课题计划项目(2018JDZX084)。
关键词 益气养阴活血汤 肾病综合征 金属蛋白酶组织抑制因子-2 T淋巴细胞亚群 白细胞介素-8 Yiqi Yangyin Huoxue Decoction Nephrotic syndrome Tissue inhibitor of metallopro-teinase-2 T lymphocyte subsets Interleukin-8
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