大黄蛭丹汤在高血压性脑出血微创手术后的临床应用

Clinical Application on Dahuang Zhidan Decoction in Hypertensive Intracerebral Hemorrhage after Minimally Invasive Operation

目的 探讨大黄蛭丹汤在高血压性脑出血微创手术后的临床应用。方法 选取2018年1月—2020年12月于项城市中医院就诊并接受高血压性脑出血微创手术的患者101例,随机数字表法分成对照组(50例)和试验组(51例),对照组给予常规治疗,试验组给予常规治疗和大黄蛭丹汤,比较2组治疗效果。结果 试验组治疗总有效率高于对照组(P<0.05),治疗后美国国立卫生院脑卒中量表(NIHSS)评分低于对照组(P<0.05),格拉斯哥昏迷指数(GCS)评分高于对照组(P<0.05),C-反应蛋白(CRP)、白细胞介素6 (IL-6)以及肿瘤坏死因子α(TNF-α)水平均低于对照组(P<0.05)。结论 大黄蛭丹汤可调节高血压性脑出血微创手术患者的炎症反应因子,改善神经功能和预后,具有一定的临床推广价值。

Objective To explore the clinical application of Dahuang Zhidan decoction in hypertensive intracerebral hemorrhage after minimally invasive surgery.Methods A total of 101 patients who received minimally invasive surgery for hypertensive cerebral hemorrhage in Xiangcheng Hospital of Traditional Chinese Medicine from January 2018 to December 2020 were selected and randomly divided into control group(50 cases) and experimental group(51 cases) by number table method.The control group received conventional treatment,and the experimental group received conventional treatment and Dahuang Zhidan decoction.The therapeutic effects of the two groups were compared.Results The total effective rate of experimental group was higher than that of control group(P<0.05),the score of National Institutes of Health Stroke Scale(NIHSS) was lower than that of control group(P<0.05),and the score of Glasgow Coma Index(GCS) was higher than that of control group(P<0.05).The levels of C-reactive protein(CRP),interleukin-6(IL-6) and tumor necrosis factor α(TNF-α) were lower than those of control group(P<0.05).Conclusion Dahuang Zhidan decoction can regulate inflammatory response factors in patients with hypertensive cerebral hemorrhage undergoing minimally invasive surgery,improve neurological function and prognosis,and has certain clinical value.