有机铬对PCOS患者临床症状的影响研究进展

Research progress of the effect of organic chromium on insulin resistance and other symptoms in PCOS patients

多囊卵巢综合征(PCOS)是妇女常见的内分泌疾病,铬(Cr)是人体基本元素之一,与机体发挥糖代谢关系紧密。目前已在大量研究中发现铬化合物能有效改善PCOS患者的体重、体质量指数(BMI)、血脂紊乱和胰岛素抵抗(IR)及高胰岛素血症(HA)等临床症状。研究表明,铬可能通过调节机体葡萄糖摄取和胰岛素敏感性通路中蛋白质与基因的表达,改善PCOS患者IR与HA等症状,然而具体分子机制尚不明确,仍需大量的实验研究。

Polycystic ovary syndrome(PCOS)is a common endocrine disease in women,but the etiology is still unclear.Chromium(Cr)is one of the basic elements of human body,which is closely related to glucose metabolism.A large number of studies have found that chromium compounds can effectively improve body weight,Body mass index,dyslipidemia and insulin resistance(IR),hyperinsulinemia(HA)in patients with PCOS.Studies have shown that chromium may improve the symptoms of IR and HA in PCOS patients by regulating the expression of proteins and genes in the glucose uptake and insulin sensitivity pathways.However,the specific molecular mechanism remains unclear,and a large number of experimental studies are needed.