甲状腺癌超声检查参数与癌症恶性程度的相关性

Correlation between Ultrasonic Parameters and Malignant Degree of Thyroid Cancer

目的探讨甲状腺癌超声检查参数与癌症恶性程度的相关性。方法选取2019年1月—2022年1月中南大学湘雅二医院桂林医院收治的经病理诊断确诊为甲状腺癌的70例患者为恶性组,另选取同期治疗的70例甲状腺结节良性病变患者作为良性组。回顾性分析其超声影像特征,并对比其超声相关参数,分析超声对甲状腺癌恶性程度的诊断价值。结果恶性组与良性组患者病灶数目、边界、形态、边缘、包膜、后方回声以及钙化情况对比,差异有统计学意义(P<0.05);恶性组始一峰时间差、上升支斜率明显高于良性组(P<0.05);Spearman相关分析结果显示:甲状腺癌超声检查参数中病灶数目、边界、形态、边缘、包膜、后方回声、钙化情况、始一峰时间差、上升支斜率与癌症恶性程度呈正相关(P<0.05);超声诊断甲状腺癌的准确率与术后病理诊断准确率对比,差异无统计学意义(P>0.05)。超声诊断甲状腺癌曲线下面积为0.828,特异度为91.25%,敏感度为72.36%,阴性预测值为66.67%,阳性预测值81.94%;病理诊断的曲线下面积为0.931,特异度为96.42%,敏感度为89.53%,阴性预测值为97.22%,阳性预测值79.19%。结论超声诊断甲状腺癌敏感度与特异度较高,并且能够通过超声图像来诊断不同形态的甲状腺癌情况,临床可通过甲状腺超声与相关指标相结合对甲状腺癌患者进行诊断。

Objective To investigate the correlation between ultrasonic parameters and malignant degree of thyroid cancer.Methods A total of 70 patients diagnosed with thyroid cancer in Second Xiangya Hospital of Central South University from January 2019 to January 2019 to January 2022 were selected as the malignant group,and other patients with benign thyroid nodules treated in the same period were selected as the benign group.The ultrasound image features and ultrasound related parameters were compared to analyze the diagnostic value of ultrasound on the malignancy of thyroid cancer.Results The number,boundary,shape,margin,capsule,posterior echo and calcification of lesions in malignant group and benign group were significantly different(P<0.05);The time difference of the first peak and the slope of ascending branch in malignant group were significantly higher than those in benign group(P<0.05);Spearman correlation analysis showed that the number,border,shape,edge,capsule,posterior echo,calcification,time difference of the first peak and the slope of ascending branch of thyroid cancer in ultrasound parameters were positively correlated with the malignant degree of cancer(P<0.05);There was no significant difference between the accuracy of ultrasound in diagnosing thyroid cancer and the accuracy of postoperative pathological diagnosis(100.00%,P>0.05).The area under the curve was 0.828,specificity 91.25%,sensitivity 72.36%,negative predictive value 66.67%,and positive predictive value 81.94%;the area under the curve was 0.931,specificity was 96.42%,sensitivity 89.53%,negative predictive value 97.22%,and positive predictive value 79.19%.Conclusion Ultrasound has high sensitivity and specificity in the diagnosis of thyroid cancer,and can diagnose different forms of thyroid cancer through ultrasound images.Clinical diagnosis of thyroid cancer can be made by combining thyroid ultrasound diagnosis with relevant indicators.