柴胡加龙骨牡蛎汤加减治疗肝郁化火型失眠的效果探讨

Discussion on the effect of modified Chaihu Longgu Muli Decoction in the treatment of insomnia with syndrome of liver depression transforming to fire

目的 探讨柴胡加龙骨牡蛎汤加减治疗肝郁化火型失眠的临床效果。方法 105例肝郁化火型失眠患者,随机分为对照组(53例)和研究组(52例)。对照组患者采取艾司唑仑片治疗,研究组患者采取柴胡加龙骨牡蛎汤加减治疗。比较两组患者治疗效果及治疗前后中医证候积分、匹兹堡睡眠质量指数量表评分。结果 研究组治疗总有效率96.15%高于对照组的77.36%,差异具有统计学意义(P<0.05)。治疗前,两组入睡困难、多梦易醒积分比较差异无统计学意义(P>0.05);治疗后,研究组入睡困难积分(1.05±0.03)分、多梦易醒积分(1.06±0.04)分均低于对照组的(1.61±0.04)、(1.88±0.05)分,差异具有统计学意义(P<0.05)。治疗前,两组匹兹堡睡眠质量指数量表评分比较差异无统计学意义(P>0.05);治疗后,研究组匹兹堡睡眠质量指数量表评分(6.23±1.83)分低于对照组的(8.15±2.02)分,差异具有统计学意义(P<0.05)。结论 肝郁化火型失眠患者选择柴胡加龙骨牡蛎汤加减治疗,可获得显著治疗效果,能有效改善患者的睡眠质量。

Objective To discuss the clinical effect of modified Chaihu Longgu Muli Decoction in the treatment of insomnia with syndrome of liver depression transforming to fire.Methods A total of 105 cases of insomnia patients with syndrome of liver depression transforming to fire were randomly divided into control group(53 cases)and research group(52 cases).The control group was treated with estazolam tablets,and the research group was treated with modified Chaihu Longgu Muli Decoction.The therapeutic effect,traditional Chinese medicine syndrome score and Pittsburgh Sleep Quality Index Scale score before and after treatment were compared between the two groups.Results The total effective rate of 96.15%in the research group was higher than that of 77.36%in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in the scores of difficulty falling asleep,dreaminess and easy waking between the two groups(P>0.05).After treatment,the score of difficulty in falling asleep,dreaminess and easy waking were(1.05±0.03)and(1.06±0.04)points in the research group,which were lower than those of(1.61±0.04)and(1.88±0.05)points in the control group,and the differences were statistically significant(P<0.05).Before treatment,there was no statistically significant difference in Pittsburgh Sleep Quality Index Scale scores between the two groups(P>0.05).After treatment,the Pittsburgh Sleep Quality Index Scale score of(6.23±1.83)points in the research group was lower than that of(8.15±2.02)points in the control group,and the difference was statistically significant(P<0.05).Conclusion Modified Chaihu Longgu Muli Decoction can achieve significant therapeutic effect for insomnia patients with syndrome of liver depression transforming to fire,and improve their sleep quality.