自身免疫性肝硬化、乙型肝炎肝硬化及酒精性肝硬化患者凝血指标及血小板计数的差异对比

Comparison on Difference of Coagulation Indicators and Platelet Count in Patients with Autoimmune Cirrhosis Hepatitis B Cirrhosis and Alcoholic Cirrhosis

目的对比分析自身免疫性肝硬化、乙型肝炎肝硬化及酒精性肝硬化患者凝血指标及血小板计数的差异。方法选择我院消化内科收治的60例肝硬化患者,分析其病历资料,并按照病因的不同分为自身免疫性肝硬化组、乙型肝炎肝硬化组与酒精性肝硬化组。对比分析三组患者的凝血指标及血小板计数的差异。结果与自身免疫性肝硬化组和酒精性肝硬化组相比,乙型肝炎肝硬化组的TT、APTT、PT、DD较高,FIB、血小板计数较低(P<0.05);与自身免疫性肝硬化组相比,酒精性肝硬化组的TT、APTT、PT、DD、FIB较高,血小板计数较低(P<0.05)。结论不同病因肝硬化对患者肝功能均有明确的损伤,且不同病因肝硬化患者凝血指标与血小板计数存在差异,可为临床鉴别诊断及不同治疗方式的选择提供依据。

Objective To compare and analyze the difference of coagulation indicators and platelet count in patients with autoimmune cirrhosis,hepatitis B cirrhosis and alcoholic cirrhosis.Methods 60 cases of patients with liver cirrhosis admitted to our Department of Hepatology from January 2019 to January 2020 were selected and divided into autoimmune cirrhosis group,hepatitis B cirrhosis group and alcoholic cirrhosis group according to different etiologies.The difference of coagulation indicators and platelet count among the three groups was compared and analyzed.Results Compared with the autoimmune cirrhosis group and alcoholic cirrhosis group,the TT,APTT,PT and DD of the hepatitis B cirrhosis group were higher,and the FIB and platelet count were lower(P<0.05);Compared with the autoimmune cirrhosis group,the TT,APTT,PT,DD and FIB of the alcoholic cirrhosis group were higher,and the platelet count was lower(P<0.05).Conclusions Liver cirrhosis of different etiologies has definite damage to the liver function of patients,and the difference of coagulation indicators and platelet count exists in patients with different cirrhosis etiologies,which can provide basis for clinical differential diagnosis and selection of different treatment methods.