督脉灸联合小剂量他达拉非治疗勃起功能障碍的疗效评价

Dumai moxibustion combined with low-dose tadalafil for erectile dysfunction:Evaluation of therapeutic effect

目的:观察督脉灸联合小剂量他达拉非治疗勃起功能障碍(命门火衰型)患者的临床疗效。方法:将符合纳入标准的130例患者随机分为对照组65例(脱落3例,完成62例)、试验组65例(脱落2例,完成63例),对照组采用小剂量他达拉非片口服,5 mg/次,1次/d;试验组在对照组的基础上联合督脉灸,1次/周,2组疗程均为4周。观察两组患者治疗前后的临床疗效、勃起功能国际问卷-5(IIEF-5)评分、勃起质量量表(EQS)评分、勃起硬度(EHS)评分、中医证候积分、TSS患者评分及阴茎血管功能指标[阴茎海绵体动脉收缩期峰值流速(PSV)、舒张末期流速(EDV)、阻力指数(RI)]。结果:试验组总有效率(87.30%)高于对照组(66.13%,P<0.05),治疗后,两组患者IIEF-5评分、EQS评分、EHS评分、TSS患者评分、PSV、RI较治疗前均升高(P<0.05),中医证候积分、EDV较治疗前均降低(P<0.05),且试验组均优于对照组(P<0.05)。结论:督脉灸联合小剂量他达拉非治疗命门火衰型勃起功能障碍患者可以改善其勃起功能与临床症状,提高患者勃起硬度、勃起质量与其治疗满意度,且能改善其阴茎血管功能,提高阴茎血流速度,临床疗效确切,具有较好安全性。

Objective:To investigate the clinical effect of dumai(governor meridian)moxibustion combined with low-dose tadalafil in the treatment of ED with decline of vital gate fire.Methods:We enrolled in this study 130 ED patients with decline of vital gate fire who met the inclusion criteria and equally randomized them into a control and an experimental group,the former treated with low-dose tadalafil tablets at 5 mg once a day while the latter by dumai moxibustion once a week in addition,all for 4 weeks.Of the total number of subjects,62 in the control group and 63 in the experimental group completed the experiment.We recorded the scores on IIEF-5,Erection Quality Scale(EQS),Erection Hardness Scale(EHS),TCM symptoms and Treatment Satisfaction Scale(TSS)as well as the penile hemodynamic parameters peak systolic velocity(PSV),end diastolic velocity(EDV)and resistance index(RI)before and after treatment and compared them between the two groups.Results:The total response rate was significantly higher in the experimental group than in the control(87.30%vs 66.13%,P<0.05).IIEF-5,EQS,EHS and TSS scores,PSV and RI were markedly increased while TCM symptoms and EDV remarkably decreased in both groups after treatment(P<0.05),even more significantly in the experimental than in the control group(P<0.05).Conclusion:Dumai moxibustion combined with low-dose tadalafil can improve erectile function,increase penile blood flow velocity and alleviate clinical symptoms in ED patients with decline of vital gate fire,with definite clinical effect and safety.