脑心通胶囊联合银杏叶提取物注射液治疗急性脑梗死患者的效果

Effect of Naoxintong Capsules combined with Ginkgo Biloba Leaves Extract Injection on acute cerebral infarction patients

目的探讨脑心通胶囊联合银杏叶提取物注射液治疗急性脑梗死(ACI)患者的效果。方法选取萍乡矿业集团有限责任公司总医院2021年4月至2022年4月收治的80例ACI患者作为研究对象,按照随机数字表法分为观察组和对照组,各40例。对照组予常规内科治疗,观察组在对照组基础上予脑心通胶囊联合银杏叶提取物注射液治疗,两组患者共治疗14d。比较两组患者的临床治疗效果,两组患者治疗前后的神经功能缺损程度评分及两组患者治疗前后的血管内皮生长因子(VEGF)和C反应蛋白(CRP)水平。结果两组患者的治疗总有效率比较,差异无统计学意义(P>0.05);观察组患者的临床治疗效果优于对照组,愈显率高于对照组,差异有统计学意义(P<0.05)。观察组患者治疗7、14d后的神经功能缺损程度评分低于对照组,差异有统计学意义(P<0.05)。观察组患者治疗后的VEGF水平高于对照组,CRP水平低于对照组,差异有统计学意义(P<0.05)。结论脑心通胶囊联合银杏叶提取物注射液治疗ACI疗效确切,可有效调节CRP及VEGF水平,促进患者神经功能恢复。

Objective To explore the effect of Naoxintong Capsules combined with Ginkgo Biloba Leaves Extract Injection in the treatment of patients with acute cerebral infarction(ACI).Methods Eighty patients with ACI admitted to General Hospital of Pingxiang Mining Group Co.,Ltd from April 2021 to April 2022 were selected as the research subjects,they were divided into observation group and control group according to the random number table method,with 40 cases in each group.The control group was given conventional medical treatment while the observation group was treated with Naoxintong Capsules combined with Ginkgo Biloba Leaves Extract Injection on the basis of the control group,patients of the two groups were treated for a total of 14 days.The clinical treatment effect of the two groups of patients,the neurological function defect score of the two groups before and after treatment and the levels of vascular endothelial growth factor(VEGF)and C-reactive protein(CRP)of the two groups of patients before and after treatment were compared.Results There was no statistically significant difference in the total effective rate of treatment between the two groups of patients(P>0.05).The clinical treatment effect of the observation group patients was better than that of the control group,the recovery rate was higher than that of the control group,the differences were statistically significant(P<0.05).The neurological function deficit score of the observation group patients after 7 and 14 days of treatment were lower than those of the control group,the differences were statistically significant(P<0.05).The VEGF level of the observation group patients after treatment was higher than that of the control group,while the CRP level was lower than that of the control group,the differences were statistically significant(P<0.05).Conclusion The combination of Naoxintong Capsules and Ginkgo Biloba Leaves Extract Injection has a definite therapeutic effect on ACI,which can effectively regulate the levels of CRP and VEGF,and promote the recovery of neurological function in patients.