植物源次生代谢产物桧木醇的研究概况

Research overview of secondary metabolite hinokitiol from plant

本文对桧木醇(hinokitiol)的发现、合成、生物活性、作用机理、非靶标毒性、衍生物等相关的研究进行了梳理分析。桧木醇是一种高活性的植物次生代谢物,具有很好的抗菌、抑菌、杀虫、抗炎、抗癌等生物活性。桧木醇可以用市场易得原料进行合成,具有很好的开发价值。桧木醇的七元环和羰基是其发挥生物活性的必要基团,其构效关系表明羟基位置的结构修饰可能是桧木醇高活性衍生物发现的重要途径之一。但是,桧木醇的作用特点、非靶标毒性、结构稳定性等还有诸多疑点未能明确,严重影响了桧木醇的应用开发。

In this paper,the research on the discovery,synthesis,biological activities,mechanism of action,non-target toxicity and derivatives of hinokitiol was reviewed.Hinokitiol is a kind of plant secondary metabolite with antimicrobial,insecticidal,anti-inflammatory,anticancer and other biological activities.It can be synthsized from readily available raw materials in industry and has significant development value.The seven-membered ring and carbonyl group of hinokitiol are essential groups for its bioactivity,and the structure-activity relationship suggests that the modification of hydroxyl group position may be one of the important ways to discover the highly active hinokitiol derivatives.However,the action characters,non-target toxicity and structural stability of hinokitiol are still unclear,which greatly limits the application of hinokitiol.