比较不同切片检测在甲状腺癌病理诊断中的应用效果

Comparison of the Effect of Different Sections in the Pathological Diagnosis of Thyroid Cancer

目的 比较不同切片诊断在甲状腺癌病理检测中的应用价值。方法 将2019年4月至2020年4月于临床实践中收集的甲状腺癌病例中抽出80例作为观察对象,均予以其进行病理诊断,分析不同切片方式在病理诊断中的应用价值,并以甲状腺石蜡切片为诊断金标准,分析冰冻切片的检出率、误诊率和延迟诊断率。结果 甲状腺石蜡切片病理诊断为良性甲状腺肿瘤、恶性甲状腺肿瘤和非甲状腺肿瘤分别25例、33例和22例;甲状腺冰冻切片病理诊断为良性甲状腺肿瘤、恶性甲状腺肿瘤和非甲状腺肿瘤分别23例、31例和20例;参考石蜡切片结果,甲状腺冰冻切片在鉴别甲状腺良恶性病变中,检测检出率、误诊率和延迟率分别为93.10%(54/58)、5.17%(3/58)、1.73%(1/58);比较不同切片组织诊断结果时间,甲状腺冰冻切片病理诊断时间为(22.54±6.14)min,较石蜡切片的(2 163.98±409.49)min短,t=17.856、P <0.05。结论 在甲状腺癌病理诊断中应用甲状腺冰冻切片,相对于石蜡切片,可有效缩减检测耗时,加快进度,且操作便捷,有较高定性判断价值。但此类切片检测也有一定不足,所以在诊断有疑虑时可联合石蜡切片进行二次诊断,避免癌肿诊断漏诊、误诊,为后续制定针对性治疗方法提供依据。

Objective To compare the utility of different section diagnosis for the pathological detection of thyroid cancer.Methods From April 2019to clinical practice collected in April 202080 cases as observation object,to the pathological diagnosis,analyze the application value of different section in pathological diagnosis,and the thyroid paraffin section as the gold standard,the analysis is the detection rate,misdiagnosis rate and delayed diagnosis rate of frozen section.Results The pathological diagnosis of thyroid paraffin section was classified as benign thyroid tumor,malignant thyroid tumor and nonthyroid tumor in 25 cases,33 cases and 22 cases,respectively.The pathological diagnosis of frozen thyroid section was benign thyroid tumor,malignant thyroid tumor and non-thyroid tumor in 23 cases,31 cases and 20 cases,respectively.Reference to the paraffin section results,frozen section of the thyroid gland in the identification of benign and malignant thyroid lesions.The detection rate,misdiagnosis rate and delay rate were 93.10%(54/58),5.17%(3/58)and 1.73%(1/58),respectively,comparing the time of diagnostic results in different sections.The time to pathological diagnosis of frozen thyroid sections was(22.54±6.14) min,shorter than(2 163.98±409.49)min of the paraffin sections,t=17.856,P<0.05.Conclusion In thyroid cancer pathological diagnosis of thyroid frozen section,relative to the paraffin section,can effectively reduce the detection time consuming,speed up the progress,and the operation is convenient,have high qualitative judgment value,but such section detection also has certain insufficiency,so when the diagnosis of doubts can combine paraffin section for secondary diagnosis,avoid cancer diagnosis missed diagnosis,misdiagnosis,for subsequent targeted treatment to provide basis.