Omicron变异株XBB.1.16流行情况和病原学特征

Research progress on the epidemic and pathogenic characteristics of Omicron variant XBB.1.16

奥密克戎变异株XBB.1.16于2023年1月9日在印度首次被发现,其病毒表面刺突(Spike,S)蛋白的E180V、T478R、F486P突变增加了病毒的传播力、致病性和免疫逃逸能力,使得在美国、印度等国家的新冠病例数激增。2023年4月17日,世界卫生组织指定XBB.1.16为感兴趣的变异株(variant of interest,VOI),但未观察到疾病严重程度的增加或额外的公共健康风险,其全球评估风险较低。本文通过文献阅读和数据库检索分析,对XBB.1.16流行情况和病原学特征进行总结,为新冠病毒防控策略的制定及疫苗、药物的研究提供科学参考。

The Omicron variant XBB.1.16 was first discovered in India on Jan 9,2023.The E180V,T478R and F486P mutations of the spike protein on the virus surface increased the transmission,pathogenicity and immune escape ability of the virus,resulting in a sharp increase in the number of COVID⁃19 cases in the United States,India and other countries.Therefore,on Apr 17,2023,XBB.1.16 was designated as a variant of interest by the World Health Organization.However,no increase in disease severity or additional public health risk were observed,resulting in a lower global assessment risk for XBB.1.16.This review summarized the global and domestic pandemic and pathogenic characteristics of XBB.1.16 through literature review and database analysis,in order to provide scientific ba⁃sis for the formulation of COVID⁃19 prevention and control strategies,as well as research on vaccines and drugs.