中性粒细胞与白蛋白比值和急性ST段抬高型心肌梗死的相关性分析

Correlation Analysis of Neutrophil-to-albumin Ratio and Acute ST-segment Elevation Myocardial Infarction

目的:探讨中性粒细胞与白蛋白比值(NAR)和急性ST段抬高型心肌梗死(STEMI)的相关性。方法:将2021年1—10月粤北人民医院收治的确诊为STEMI并在胸痛12 h内行经皮冠状动脉介入治疗(PCI)的80例患者设为研究组,并选取同年1—10月40例健康体检者设为对照组,回顾性分析研究组及对照组的临床资料。比较两组患者白细胞计数(WBC)、中性粒细胞计数(N)、中性粒细胞百分比计数(NP)、淋巴细胞计数(L)、白蛋白(ALB)、中性粒细胞与淋巴细胞比值(NLR)、中性粒细胞与白蛋白比值(NAR)、中性粒细胞百分比与白蛋白比值(NPAR)等指标。采用二元logistics回归检验NAR和STEMI发病的相关性。用ROC曲线比较N、NAR、NLR、NPAR对STEMI的诊断价值。结果:研究组WBC、N、NP、HbA1c、NLR、NAR、NPAR均高于对照组,差异有统计学意义(U=-6.85、-8.02、-7.76、-3.47、-7.77、-8.38、-8.12,P<0.05);研究组L、ALB、TC、HDL-C均低于对照组,差异有统计学意义(U=-5.82、-6.68、-2.17、-5.28,P<0.05)。NAR可能是STEMI的独立危险因素。NAR的ROC曲线下面积高于N、NLR及NPAR。结论:NAR与STEMI发病相关,可能是STEMI的独立危险因素,对STEMI的早期诊断有一定的意义,其诊断价值可能优于N、NLR及NPAR,且有助于STEMI的早期预防,减少STEMI的发病率。

Objective:To investigate the correlation between neutrophil-to-albumin ratio(NAR) and acute ST-segment elevation myocardial infarction(STEMI).Methods:A total of 80 patients diagnosed with STEMI and undergoing PCI within 12 h of chest pain admitted to the hospital from January to October 2021 were set up as the study group,and 40 healthy physical examination patients from January to October of the same year were selected as the control group,and the clinical data of the study group and the control group were retrospectively analyzed.The white blood cell count(WBC),neutrophil count(N),neutrophil percentage count(NP),lymphocyte count(L),albumin(ALB),neutrophil-to-lymphocyte ratio(NLR),neutrophil-to-albumin ratio(NAR),and neutrophil percentage to albumin ratio(NPAR) were compared between the two groups.Binary logistic regression was used to test the correlation between NAR and STEMI onset.ROC curves were used to compare the diagnostic value of N,NAR,NLR,and NPAR for STEMI.Results:WBC,N,NP,HbA1c,NLR,NAR,NPAR were higher in the study group than in the control group,with statistically significant difference(U=-6.85,-8.02,-7.76,-3.47,-7.77,-8.38,-8.12,P<0.05).L,ALB,TC,HDL-C were lower than in the control group,with statistically significant differences(U=-5.82,-6.68,-2.17,-5.28,P<0.05).NAR may be an independent risk factor for STEMI.The area under the ROC curve for NAR was higher than that for N,NLR and NPAR.Conclusion:NAR is associated with the onset of STEMI,may be an independent risk factor for STEMI,has some significance for the early diagnosis of STEMI,its diagnostic value may be better than N,NLR and NPAR,and helps in the early prevention of STEMI and reduce the incidence of STEMI.