以线粒体自噬为靶点的益气活血类中药保护心肌缺血再灌注损伤研究进展

Research progress on the protection of myocardial ischemia-reperfusion injury by Qi-enhancing and blood-activating traditional Chinese medicines targeting mitochondrial autophagy

线粒体自噬是一种高度保守的线粒体降解过程。适当的线粒体自噬有利于维持心肌细胞内稳态,对保护缺血心肌具有重要意义。大量研究证实,中药单体、组分、复方可通过保护线粒体结构及功能,调节线粒体自噬,有效治疗缺血性心脏病。基于上述背景,本文以线粒体自噬为靶点,通过PINK1-Parkin、FUNDC1、BNIP3L/NIX等信号通路,对益气活血类中药提取物或复方在缺血性心脏病中的作用和机制进行综述,并结合实验室研究结果,为阐述益气活血类中药调控线粒体自噬的作用机制提供合理依据,以期为防治缺血性心脏病提供有效策略。

Mitochondrial autophagy is a highly conserved mitochondrial degradation process.Proper mitochondrial autophagy is beneficial to maintain homeostasis of cardiomyocytes and has important significance for protection of ischemic myocardium.A large number of studies have confirmed that TCM monomers,components and compounds can effectively treat ischemic heart disease by protecting mitochondrial structure and function,regulating mitochondrial autophagy.Based on the above background,this paper took mitochondrial autophagy as the target and reviewed the mechanisms of Qi-enhancing and blood-activating Chinese herbal extracts or compounds in ischemic heart disease through PINK1-Parkin,FUNDC1,BNIP3L/NIX and other signaling pathways.Combined with the results of our laboratory,in order to provide a reasonable basis for explaining the mechanism of regulating mitochondria autophagy by TCM of invigorating Qi and promoting blood circulation,and to provide effective strategies for preventing and treating ischemic heart disease.