扩张型心肌病患者血清GDF-15、Gal-3水平与心肌损伤、预后的相关性分析

Relationship analysis between serum GDF-15 and Gal-3 levels and myocardial injury and prognosis in patients with dilated cardiomyopathy

目的:探讨扩张型心肌病(DCM)患者血清生长分化因子-15(GDF-15)、半乳糖凝集素-3(Gal-3)水平与心肌损伤、预后的关系。方法:选取72例DCM患者为DCM组,另取同期体检健康者40例为对照组。测定两组受试者GDF-15和Gal-3水平,分析GDF-15和Gal-3及联合诊断DCM的价值;分析GDF-15和Gal-3水平与心肌损伤程度及预后的关系。结果:DCM组GDF-15和Gal-3水平高于对照组(P<0.05);GDF-15和Gal-3联合诊断DCM的AUC高于单项诊断(P<0.05);随着心肌损伤程度加重,患者GDF-15和Gal-3水平升高(P<0.05);随着疗效提升,患者GDF-15和Gal-3水平降低(P<0.05)。结论:GDF-15和Gal-3在DCM的早期诊断中价值较高,且联合诊断价值更高;GDF-15和Gal-3与DCM患者的心肌损伤程度和预后密切相关。

Objective:To investigate the relationships between serum growth differentiation factor-15(GDF-15)and galectin-3(Gal-3)levels and myocardial injury and prognosis in patients with dilated cardiomyopathy(DCM).Methods:A total of 72 patients with DCM and 40 healthy controls were selected as the DCM group and control group,respectively.The levels of GDF-15 and Gal-3 in both groups were detected for the analysis of the values of GDF-15,Gal-3 and combined diagnosis of DCM,then,the relationships between GDF-15 and Gal-3 levels and the severity of myocardial injury and prognosis of patients were analyzed.Results:The levels of GDF-15 and Gal-3 in DCM group were higher than those in the control group(P<0.05);area under the curve(AUC)of the combined diagnoses of GDF-15with Gal-3 was higher than that of single diagnosis(P<0.05);the levels of GDF-15 and Gal-3 increased with the severity of myocardial injury(P<0.05);and with the improvement of curative effect,levels of GDF-15 and Gal-3 decreased(P<0.05).Conclusion:GDF-15 and Gal-3 have higher values in the early diagnosis of patients with DCM,and the combined diagnosis has even higher values;GDF-15 and Gal-3 are closely related to the severity of myocardial injury and prognosis in DCM patients.