子宫内膜增生、Ⅰ型子宫内膜癌的PAX-2及β-catenin表达情况

PAx-2 analysis of endometrial hyperplasia and type I endometrial cancerβ-expression of catenin

目的 分析子宫内膜增生、Ⅰ型子宫内膜癌的PAX-2及β-catenin表达情况。方法 选取本院经手术病理检查确诊的40例子宫内膜增生患者、40例Ⅰ型子宫内膜癌患者为研究对象,均行PAX-2、β-catenin检测,比较表达情况。结果 子宫内膜增生组PAX-2表达缺失率为42.50%,低于Ⅰ型子宫内膜癌组的92.50%,差异有统计学意义(P<0.05);复杂增生组PAX-2正常表达率为80.00%,高于单纯性增生组的70.00%与非典型增生组的33.33%,差异有统计学意义(P<0.05);Ⅰ型子宫内膜癌Ⅲ级组PAX-2完全缺失率为83.33%,高于Ⅱ级组的72.73%与Ⅰ级组的33.33%,差异有统计学意义(P<0.05);β-catenin表达未见显著差异(P>0.05)。结论 PAX-2表达缺失率在子宫内膜增生发展至子宫内膜癌进程中不断升高,能够为疾病诊断及病情评估提供一定参考。

Objective To analyze the PAX-2 expression of endometrial hyperplasia and typeⅠ endometrial cancerβ-expression of catenin.Methods 40 patients with endometrial hyperplasia and 40 patients with type I endometrial cancer confirmed by surgical and pathological examination in our hospital were selected as the research subjects,and PAx-2 was detectedβ-catenin,compare the expression situation.Results The loss rate of PAx-2 expression in the endometrial hyperplasia group was 42.50%,lower than 92.50%in the type I endometrial cancer group,with a statistically significant diference(P<0.05);The normal expression rate of PAx-2 in the complex hyperplasia group was 80.00%,which was higher than 70.00%in the simple hyperplasia group and 33.33%in the atypical hyperplasia group,with a statistically significant difference(P<0.05);The complete loss rate of PAX-2 in grade II group of type I endometrial cancer was 83.33%,which was higher than 72.73%in grade IIgroup and 33.33%in grade I group,with a statistically significant difference(P<0.05);β-There was no significant difference in catenin expression(P>0.05).Conclusion The loss rate of PAX-2 expression continues to increase during the progression of endometrial hyperplasia to endometrial cancer,which can provide a certain reference for disease diagnosis and condition evaluation.